Zobrazeno 1 - 10
of 298
pro vyhledávání: ''
Autor:
Osamu Ezaki, Yuko Kai, Junya Fujimaki, Yasutomi Kamei, Haruka Ajima, Shiori Akashi, Akihito Morita, Shinji Miura
Publikováno v:
The Journal of Toxicological Sciences. 46:11-24
Fibrates and statins have been widely used to reduce triglyceride and cholesterol levels, respectively. Besides its lipid-lowering effect, the side effect of muscle atrophy after fibrate administration to humans has been demonstrated in some studies.
Publikováno v:
The Journal of Toxicological Sciences. 46:345-358
Pb exposure is a worldwide environmental contamination issue which has been of concern to more and more people. Exposure to environmental Pb and its compounds through food and respiratory routes causes toxic damage to the digestive, respiratory, card
Publikováno v:
The Journal of Toxicological Sciences. 46:311-317
The approved drug thalidomide is teratogenic in humans, nonhuman primates, and rabbits but not in rodents. The extensive biotransformation of 5'-hydroxythalidomide after oral administration of thalidomide (250 mg/kg) in rats was investigated in detai
Publikováno v:
The Journal of Toxicological Sciences. 45:95-108
We present a systematic, comprehensive and reproducible weight-of-evidence approach for predicting the no-observed-adverse-effect level (NOAEL) for systemic toxicity by using read-across and quantitative structure-activity relationship (QSAR) models
Publikováno v:
The Journal of Toxicological Sciences. 45:373-390
DEHP (di-2-ethylhexyl phthalate), an environmental endocrine disruptor, is widely used in industrial products, particularly as plasticizers and softeners which could disrupt the function of the hypothalamic-pituitary-thyroid (HPT) axis. Rosmarinic ac
Publikováno v:
The Journal of Toxicological Sciences. 45:435-447
The imbalance of testosterone to estradiol ratio has been related to the development of prostate diseases. Although rat models of prostate diseases induced by endocrine-disrupting chemicals (EDCs) and/or hormone exposure are commonly used to analyze
Publikováno v:
The Journal of Toxicological Sciences. 45:611-617
Acute paraquat poisoning (APP) is a serious public health problem with a high mortality rate and there is no specific antidote for APP in clinical. Early haemoperfusion (HP) treatment is effective in APP rescue. In this study, we compared the influen
Publikováno v:
The Journal of Toxicological Sciences. 45:783-794
Bisphenol A (BPA) interferes the function and development of the central nervous system (CNS), resulting in behavioral abnormalities and memory loss. S-nitrosylation of protein disulfide isomerase (PDI) is increased in brains with sporadic Alzheimer'
Autor:
Kazuma Kondo, Kouichi Yoshinari, Yusuke Suzuki, Kaoru Toyoda, Akio Kobayashi, Naohito Yamada, Tatsuji Hashimoto, Shoichiro Sugai, Tadakazu Takahashi
Publikováno v:
The Journal of Toxicological Sciences. 45:245-260
Some patients encounter hepatotoxicity after repeated acetaminophen (APAP) dosing even at therapeutic doses. In the present study, we focused on the diabetic state as one of the suggested risk factors of drug-induced liver injury in humans and invest
Autor:
Toru Yamada, Izuru Miyawaki, Izumi Matsumoto, Yuta Fujii, Akihito Yamashita, Mami Kouchi, Tomoaki Tochitani
Publikováno v:
The Journal of Toxicological Sciences. 44:575-584
The adrenal gland is the most common toxicological target of drugs within the endocrine system, and inhibition of adrenal steroidogenesis can be fatal in humans. However, methods to evaluate the adrenal toxicity are limited. The aim of the present st