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Publikováno v:
The Journal of Toxicological Sciences. 39:339-351
Although some studies have described the function of ADAM8 (a disintegrin and metalloprotease 8) related with rheumatoid arthritis, cancer and asthma, etc., the concrete role of ADAM8 in acute liver injury is still unknown. So mice respectively recei
Publikováno v:
The Journal of Toxicological Sciences. 39:551-559
Particulate air pollutants and mineral fibers activate inflammatory cells to release oxidants, which contribute to inflammation and injury in the lower respiratory tract. Our aim was to compare the role of silica particle size with mineral fiber leng
Autor:
Ryuichi Komatsu, Mitsuyasu Tabo, Shino Kuramoto, Hidetoshi Shindoh, Takehito Isobe, Masaki Honda
Publikováno v:
The Journal of Toxicological Sciences. 39:237-242
Anti-angiogenic drugs that target Vascular Endothelial Growth Factor (VEGF) signaling pathways caused hypertension as an adverse effect in clinical studies. Since the hypertension may limit the benefit provided for patients, the demand for non-clinic
Autor:
Yoko Watanabe, Shigeru Ohta, Shigeyuki Kitamura, Hidenari Shigematsu, Toshio Inoue, Naoto Uramaru
Publikováno v:
The Journal of Toxicological Sciences. 39:83-90
Parabens, which are a homologous series of esters of p-hydroxybenzoic acid, have been used as preservatives in cosmetics, medicines and foods because of their antimicrobial activity. However, parabens in cosmetics have been suspected to cause allergi
Publikováno v:
The Journal of Toxicological Sciences. 39:849-859
The present report was designed to determine the antigenotoxic capacity of beta-caryophyllene (BC) on the damage induced by benzo(a)pyrene (BaP) in mouse. We found no genotoxic potential of BC, and a significant inhibitory effect on the number of sis
Autor:
Naoki Kakurai, Akira Hiratsuka, Nahoko Hayashi, Takahito Nishiyama, Ai Kuriyama, Chika Miyamoto, Tomokazu Ohnuma, Hiromi Yanagita, Yumi Ishihara, Kenichiro Ogura
Publikováno v:
The Journal of Toxicological Sciences. 39:515-521
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, induced lung tumors in rodents and is likely involved in human lung cancer. 4-(Hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (HO-methyl NNK) glucuronide, a glu
Publikováno v:
The Journal of Toxicological Sciences. 39:425-435
Chlorpyrifos (CPF) is an organophosphate compound that is slowly delivered in the organism after subcutaneous injection, keeping acetylcholinesterase (AChE) activity mildly inhibited for weeks. We have previously reported reduced voluntary ethanol dr
Autor:
Hiroaki Todo, Hideto Jinno, Kiyomi Tsuji, Hiroshi Tokunaga, Masahiro Sugino, Kenji Sugibayashi, Takamasa Suzuki, Keiichi Nakada
Publikováno v:
The Journal of Toxicological Sciences. 39:475-485
Advances in the synthesis and utilization of new chemical compounds have led to improvements in our daily lives. However, new chemicals may be both beneficial and toxic. Thus, exposure to these new compounds should be restricted in an attempt to limi
Publikováno v:
The Journal of Toxicological Sciences. 39:701-710
While the immunotoxicity of endosulfan has been studied, little is known about its influence on immune function associated with erythrocytes (RBC). The aim of this study was to investigate the possible effects of endosulfan, and any possible mitigati
Autor:
Keiichi Minami, Takeki Uehara, Ko Omura, Kunitoshi Mitsumori, Masayuki Kanki, Tetsuro Urushidani, Yuji Morikawa, Hitomi Hayashi, Atsushi Ono, Hiroshi Yamada
Publikováno v:
The Journal of Toxicological Sciences. 39:785-794
We previously reported a toxicogenomics-based prediction model for hepatocarcinogens in which the expression patterns of signature genes following repeated doses of either genotoxic or non genotoxic compounds were similar. Based on the results of our