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Publikováno v:
The Journal of Toxicological Sciences. 46:311-317
The approved drug thalidomide is teratogenic in humans, nonhuman primates, and rabbits but not in rodents. The extensive biotransformation of 5'-hydroxythalidomide after oral administration of thalidomide (250 mg/kg) in rats was investigated in detai
Publikováno v:
The Journal of Toxicological Sciences. 43:311-319
Emerging evidence has demonstrated that iron overload plays an important role in oxidative stress in the liver. This study aimed to explore whether fluoride-induced hepatic oxidative stress is associated with iron overload and whether grape seed proa
Publikováno v:
The Journal of Toxicological Sciences. 39:339-351
Although some studies have described the function of ADAM8 (a disintegrin and metalloprotease 8) related with rheumatoid arthritis, cancer and asthma, etc., the concrete role of ADAM8 in acute liver injury is still unknown. So mice respectively recei
Publikováno v:
The Journal of Toxicological Sciences. 39:849-859
The present report was designed to determine the antigenotoxic capacity of beta-caryophyllene (BC) on the damage induced by benzo(a)pyrene (BaP) in mouse. We found no genotoxic potential of BC, and a significant inhibitory effect on the number of sis
Publikováno v:
The Journal of Toxicological Sciences. 39:1-6
1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (α-PVP) is a new designer drug of the cathinone type. People who have taken drugs containing α-PVP or other synthetic cathinone reportedly lose consciousness, develop difficulty breathing, and at worst case,
Autor:
Haruhiko Yoshinari, Yoshinori Shibaike, Masafumi Tomita, Yoko Watanabe, Hironobu Katsuyama, Osamu Miyamoto, Jia Wei Tee, Nobuhisa Iwachidou
Publikováno v:
The Journal of Toxicological Sciences. 38:671-678
Methamphetamine (METH) is a powerful and toxic psychostimulant that is abused worldwide. Although many studies of its toxic functions have been done on animals and humans, the mechanism is still poorly understood. In addition, the doses of METH exami
Publikováno v:
ResearcherID
We previously reported that 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) increased the levels of several cytochrome P450 metabolites of the omega-6 polyunsaturated fatty acids (PUFAs), arachidonic acid (ARA) and linoleic acid in the serum, liver, lung
Publikováno v:
The Journal of Toxicological Sciences. 38:703-706
Metabolomic analysis was performed using the cerebellum of methylmercury-treated mice to elucidate the molecular mechanisms underlying methylmercury-induced cerebellar dysfunction. Methylmercury administration led to significant increases in the leve
Autor:
Masahiko Satoh, Makoto Seo, Hiroichi Nagai, Tetsunori Okamura, Koji Ikeda, Hisamitsu Nagase, Ryo Kobayashi, Naoki Inagaki
Publikováno v:
The Journal of Toxicological Sciences. 37:439-445
Trichloroethylene (TCE) and tetrachloroethylene (perchloroethylene; PCE) are commonly identified as environmental contaminants of groundwater. Previously, we investigated the enhancing effects of TCE and PCE on antigen-induced histamine release and i
Autor:
Ken Ichi Aisaki, Satoshi Kitajima, Noriko Moriyama, Katsuhide Igarashi, Nae Matsuda, Yuhji Taquahashi, Jun Kanno, Eriko Ikeno, Bruce Blumberg, Kentaro Tanemura, Yumiko Saga
Publikováno v:
The Journal of Toxicological Sciences. 37:373-380
The human steroid and xenobiotic receptor (SXR), (also known as pregnane X receptor PXR, and NR1I2) is a low affinity sensor that responds to a variety of endobiotic, nutritional and xenobiotic ligands. SXR activates transcription of Cytochrome P450,