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Autor:
Zhao Junwei, Long Xu, Limeng Wang, Xiujie Pan, Jianping Xie, Xing-yu Liu, Xiang Li, Mao-xiang Zhu, Zhi-hua Yang
Publikováno v:
The Journal of Toxicological Sciences. 43:33-44
Crotonaldehyde is a ubiquitous air pollutant in the environment. It is reported to be harmful to the biosystems in vivo and in vitro. The exposure to crotonaldehyde irritates the mucous membranes and induces edema, hyperemia, cell necrosis, inflammat
Publikováno v:
The Journal of Toxicological Sciences. 41:17-24
Didecyldimethylammonium chloride (DDAC), an antimicrobial agent, has been reported to induce pulmonary toxicity in animal studies. DDAC is frequently used in spray-form household products in combination with ethylene glycol (EG). The purpose of this
Publikováno v:
The Journal of Toxicological Sciences. 41:245-253
We previously reported that thioacetamide (TA)-induced hepatocellular necrosis was attenuated in mice fed a high-fat diet (HFD mice) compared with mice fed a normal rodent diet (ND mice). In this study, we investigated whether p38 mitogen-activated p
Autor:
Min-Sung Kang, Kyunghee Choi, Jung-Taek Kwon, Hyun-Mi Kim, Gyun-Baek Seo, Ilseob Shim, Young-Su Yang, Mi-Jin Yang, Pilje Kim, Kyuhong Lee, Dong-Hun Lee
Publikováno v:
The Journal of Toxicological Sciences. 38:471-475
Triclosan (TCS) is a chemical compound used in household products as biocide. However, their pulmonary toxicity has been unclear. Thus, the purpose of this study was to investigate the possibility of injury to the lung by inhalation of TCS. Rats were
Publikováno v:
ResearcherID
Volatile organic compounds (VOCs) are the main substances causing multiple chemical sensitivity reactions in human. The effects of single VOCs exposure on airway inflammatory responses in mice lung have been reported. Previous studies have demonstrat
Autor:
Olawale Yakubu Adeniran, Adetola Folusho Lawal, Federick Obi, A Ologundudu, Akhere A. Omonkhua, AO Lawal
Publikováno v:
The Journal of Toxicological Sciences. 36:549-557
The antioxidant efficacy of heated garlic juice (HGJ) in liver was evaluated with that of ascorbic acid (AA) in rats exposed to acute dose of cadmium (4 mg kg(-1) bd. wt). The rats were either given HGJ (100 mg kg(-1) bd. wt) orally, daily for 4 week
Autor:
Shogo Sato, Kyoko Kobayashi, Yui Someya, Hisashi Ideno, Yu Kawashima, Ken Shirato, Kaoru Tachiyashiki, Kazuhiko Imaizumi
Publikováno v:
The Journal of Toxicological Sciences. 36:347-355
Acute single administration effects of ethanol on the distribution of total white blood cells (WBCs), neutrophil, basophil, eosinophil, monocyte and lymphocytes were studied in rats. Acute single administration effects of ethanol on the number of red
Autor:
Daichi Nakamura, Takumi Ohishi, Yoshito Nishihara, Masahiro Mochizuki, Takahiro Kitazawa, Saori Suzuki
Publikováno v:
The Journal of Toxicological Sciences. 35:189-196
Effects of pregnancy and lactation on warfarin-induced changes in blood coagulation-related parameters were examined in rats. Warfarin (0.5 mg/kg/day) was given orally to pregnant and non-pregnant rats for 3 days from gestation day (GD) 17 to 19 or t
Autor:
Norio Imai, Mayumi Kawabe, Kazuo Yasuhara, Satoshi Kitamura, Seiko Tamano, Masashi Sano, Iwao Asai, Shim-mo Hayashi, Akihiro Hagiwara, Toshio Omoto
Publikováno v:
The Journal of Toxicological Sciences. 35:317-325
This study was designed to evaluate any adverse effect of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, when administered to both sexes of F344 rats at dietary levels of 0, 1.25, 2.5, and 5.0% for 28 days. The trea
Autor:
Debabrata Chanda, Karuna Shanker, Mahendra P. Darokar, Suaib Luqman, Dayanandan Mani, Dnyaneshwar U. Bawankule, Anirban Pal
Publikováno v:
The Journal of Toxicological Sciences. 34:99-108
Chemical characterization and acute and sub-acute toxicity study of Trikatu, a generic herbal formulation of Indian system of medicine, was carried out in Charles Foster (CF) rats for safety profiling. In acute toxicity experiment, Trikatu at 2,000 m