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Publikováno v:
The Journal of Toxicological Sciences. 45:783-794
Bisphenol A (BPA) interferes the function and development of the central nervous system (CNS), resulting in behavioral abnormalities and memory loss. S-nitrosylation of protein disulfide isomerase (PDI) is increased in brains with sporadic Alzheimer'
Autor:
Wei Liu, Shuji Tsuda, Fukiko Ueda, Daichi Mazawa, Katsumi Iwabuchi, Itaru Sato, Michihiro Hara, Norimasa Senzaki
Publikováno v:
The Journal of Toxicological Sciences. 42:301-317
To examine the kinetics of low doses of perfluoro compounds (PFCs), we administered perfluorohexanoic acid (C6A), perfluorooctanoic acid (C8A), perfluorononanoic acid (C9A) and perfluorooctane sulfonate (C8S) with a single oral dose (50-100 μg/kg BW
Publikováno v:
The Journal of Toxicological Sciences. 39:425-435
Chlorpyrifos (CPF) is an organophosphate compound that is slowly delivered in the organism after subcutaneous injection, keeping acetylcholinesterase (AChE) activity mildly inhibited for weeks. We have previously reported reduced voluntary ethanol dr
Autor:
Haruhiko Yoshinari, Yoshinori Shibaike, Masafumi Tomita, Yoko Watanabe, Hironobu Katsuyama, Osamu Miyamoto, Jia Wei Tee, Nobuhisa Iwachidou
Publikováno v:
The Journal of Toxicological Sciences. 38:671-678
Methamphetamine (METH) is a powerful and toxic psychostimulant that is abused worldwide. Although many studies of its toxic functions have been done on animals and humans, the mechanism is still poorly understood. In addition, the doses of METH exami
Autor:
Ioannis Taitzoglou, Efstathios Nikolaidis, Eleni K. Eleftheriadou, Ioannis Zervos, Maria Tsantarliotou, Sophia Lavrentiadou, Elias P. Papapanagiotou, Dimitrios J. Fletouris, Marios P. Georgiadis
Publikováno v:
The Journal of Toxicological Sciences. 36:423-433
Endosulfan provokes systemic toxicity in mammals and induces reactive oxygen species (ROS) and lipid peroxidation (LPO). The brain is susceptible to LPO and several studies implicate ROS and LPO in CNS diseases. Tissue plasminogen activator (t-PA) ha
Autor:
Shuji Tsuda, Midori Yoshida, Yihe Jin, Itaru Sato, Kosuke Kawamoto, Norimitsu Saito, Kaori Yaegashi, Wei Liu
Publikováno v:
The Journal of Toxicological Sciences. 36:55-62
Perfluorooctane sulfonate (PFOS) is one of the persistent organic pollutants distributed widely in the global environment. We have found that a single oral administration of PFOS induced tonic convulsion in mice and rats when a brief ultrasonic stimu
Publikováno v:
The Journal of Toxicological Sciences. 35:721-730
Formaldehyde (FA) is a commonly used chemical in everyday life and can react with many molecules in the human body. Although toxicity has been reported, exposure to FA has also been shown to have beneficial effects or no effect at all. In the present
Autor:
Hongyao Yu, Shuji Tsuda, Li Liu, Norimitsu Saito, Yihe Jin, Kazunori Oami, Jinlan Song, Itaru Sato, Wei Liu
Publikováno v:
The Journal of Toxicological Sciences. 34:245-254
Eeffects of perfluorooctane sulfonate (PFOS) on maleic dialdehyde (MDA) content, superoxide dismutase (SOD) activity and total antioxidation capability (T-AOC) were compared in mice at different postnatal developmental stages, and concentrations and
Autor:
Kentaro Tanemura, Ken Ichi Aisaki, Jun Kanno, Satoshi Kitajima, Katsuhide Igarashi, Toshiko R. Matsugami
Publikováno v:
The Journal of Toxicological Sciences. 34:SP279-SP286
To demonstrate induction of delayed central nervous toxicity by disturbing neuronal activities in the developing brain, we administered a single intraperitoneal dose of domoic acid (DA; 1 mg/kg), a potent glutamate receptor agonist, to pregnant femal
Publikováno v:
The Journal of Toxicological Sciences. 28:427-438
The neurochemical and behavioral effects of repeated subdermal administration of methyl parathion (MP) at low doses were investigated. Adult male rats were treated repeatedly with either vehicle or MP subcutaneously (3 mg/kg/day) and observed for the