Zobrazeno 1 - 10
of 60
pro vyhledávání: ''
Autor:
Beatriz Gálvez-Prieto, M. Carmen González, M. Victoria Cano, María S. Fernández-Alfonso, Maik Gollasch, Isabel Aranguez, Galyna Dubrovska, Mercedes Delgado, Mariano Ruiz-Gayo
Publikováno v:
Hypertension Research. 31:1415-1423
The aim of this study was to determine whether alterations in periadventitial adipose tissue and its anti-contractile effect precede hypertension development. We used 4-week-old male Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR), which
Publikováno v:
Hypertension Research. 31:2177-2186
Adenosine is known to modulate neuronal activity within the nucleus tractus solitarius (NTS). The modulatory effect of adenosine A1 receptors (A1R) on alpha2-adrenoceptors (Adr2R) was evaluated using quantitative radioautography within NTS subnuclei
Autor:
Tetsuya Tatsumi, Eri Gouda, Nana Tanaka, Miyuki Kobara, Hiroyuki Yamada, Hiroaki Matsubara, Tetsuo Nakata, Hironori Hayashi, Hiroe Toba, Masaki Abe
Publikováno v:
Hypertension Research. 31:363-375
The roles of aldosterone in the progression of heart failure have not been fully elucidated. This study examined whether aldosterone nongenomically activates reactive oxygen species (ROS) production, causing myocyte apoptosis. Addition of aldosterone
Publikováno v:
Hypertension Research. 30:1247-1254
Accumulating evidence suggests an important role of the calcineurin signaling pathway in mediating the development of cardiac hypertrophy. It has also been reported that angiotensin-converting enzyme inhibitors (ACEIs) regressed cardiac hypertrophy i
Autor:
Harry A.J. Struijker-Boudier, Marc A J M van Zandvoort, Sebastian Dolff, Remco T. A. Megens, Marcus Baumann, Roger Bartholome, Jos F.M. Smits, Jo G. R. De Mey
Publikováno v:
Hypertension Research. 30:853-861
Arterial function after long-term hypertension is characterized by remodeling, endothelial dysfunction and reduction of previously enhanced contractile responses. We investigated whether transient prehypertensive renin-angiotensin-aldosterone system
Autor:
Toshiro Fujita, Tatsuo Shimosawa, Hiromitsu Matsui, Yoko Hirano, Makoto Tsunoda, Takashi Funatsu
Publikováno v:
Hypertension Research. 30:269-278
Catecholamines have been reported to be involved in the development of salt-sensitive hypertension. We investigated the relation between catechol-O-methyltransferase (COMT) and salt-sensitivity. In the first experiment, Dahl salt-sensitive (DS) rats
Autor:
Manabu Ishihara, Koichiro Tsuchiya, Toshiaki Tamaki, Yuki Izawa, Yasuhisa Kanematsu, Hideki Ohnishi, Keisuke Ishizawa, Kazuyoshi Kawazoe, Shinji Abe, Yuki Motobayashi
Publikováno v:
Hypertension Research. 29:369-374
We previously succeeded in measuring the nitrosylhemoglobin (HbNO) level as an index of blood nitric oxide (NO) by the electron paramagnetic resonance (EPR) HbNO signal subtraction method. In this study, we examined the effects of olmesartan, an angi
Autor:
Mamoru Fujita, Akira Nishiyama, Akira Miyatake, Shoji Kimura, Yukiko Nagai, Youichi Abe, Guang-Ping Sun, Naohisa Hosomi, Ryoko Baba, Yu-Yan Fan, Masakazu Kohno
Publikováno v:
Hypertension Research. 29:169-178
Recent studies have suggested that aldosterone plays a role in the pathogenesis of renal injury. In this study, we investigated whether local angiotensin II (Ang II) activity contributes to the progression of renal injury in aldosterone/salt-induced
Autor:
Akio Yoshida, Shinobu Sugihara, Osamu Igawa, Yasuhiro Kaetsu, Chiaki Shigemasa, Tetsuya Yamamoto, Ichiro Hisatome, Junichiro Miake, Toshihiro Hamada, Takashi Matsuura, Kazuhide Ogino, Yasutaka Yamamoto, Go Igawa, Koichi Matsubara
Publikováno v:
Hypertension Research. 29:915-921
Uric acid and oxidative stress promote cardiovascular diseases, including atherosclerosis and hypertension. Xanthine oxidase, through which uric acid is generated, is a free-radical generating enzyme. The aim of the current study was to investigate w
Publikováno v:
Hypertension Research. 29:95-104
Experimental evidence has suggested that vascular adventitial fibroblasts (AFs) may migrate into the neointima of arteries after balloon injury in various animal models. However, the research on migration of AFs has been limited to the effects of acu