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Publikováno v:
The Journal of Antibiotics. 44:441-444
Pharmacokinetic properties of WF-3681 and FR-62765 in rats were examined. FR-62765 showed higher peak concentrations in the plasma and higher concentrations in the sciatic nerve than WF-3681 when each compound was administered orally to rats. We ther
Publikováno v:
The Journal of Antibiotics. 45:806-808
Publikováno v:
The Journal of Antibiotics. 37:1066-1075
A study on the pharmacokinetics of rifapentine, a new long-lasting rifamycin, has been carried out in the rat, the mouse and the rabbit. The investigation was made using either radioactive or unlabelled rifapentine and both the total 14C and the unch
Autor:
Masaaki Ishizuka, Katsutoshi Takahashi, Takumi Yamashita, Makoto Enomoto, Kyoichi Shibuya, Hamao Umezawa, Kazuo Ebihara, Fuminori Abe, Hiroo Horinishi, Emiko Hayashi
Publikováno v:
The Journal of Antibiotics. 39:966-970
The effect of ubenimex on the progression of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced stomach tumor in rats was studied. Tumor induction was performed by giving MNNG via drinking water for 34 weeks. Ubenimex was ip administered twice a wee
Autor:
De Marchi F, Amalia Guaitani, Franco Casacci, F. Corti, Ernesto Pacei, Ivan Bartošek, Pia Villa
Publikováno v:
The Journal of Antibiotics. 39:839-845
The hepatic clearance and the effects of a new fluorinated macrolide (P-0501A) on the functions of the isolated, perfused rat liver were compared with two known erythromycins--the base and the estolate--after 7 days of treatment (1.36 mmol/kg po dail
Publikováno v:
The Journal of Antibiotics. 38:496-504
The pharmacokinetics of FK027, a new oral cephalosporin, were investigated in rats and dogs and compared with those of cefaclor, cephalexin and amoxicillin. Upon oral administration to either rats or dogs, FK027 produced higher and more sustained ser
Autor:
Hiroyuki Arakawa, Miho Tanaka, Masashi Yagi, Osamu Nakayama, Masanobu Kohsaka, Sumio Kiyoto, Masakuni Okuhara
Publikováno v:
The Journal of Antibiotics. 42:1235-1240
WS-9659 A, a novel phenazine, produced by a Streptomyces sp., had testosterone 5 alpha-reductase inhibition activity on rat, dog and human prostates. However, WS-9659 A did not show any inhibitory activities for aldose reductase on rabbit lenses and