Zobrazeno 1 - 10
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Autor:
Jie Zhang, Weilong Zhong, Simin Zhou, Xiaoyi Wang, Jingwen Zhao, Man Liu, Lu Zhang, Lu Zhou, Xin Liu, Bangmao Wang, Hongxia Zhang
Publikováno v:
International Journal of Biological Sciences
Autoimmune hepatitis (AIH) is an immune-mediated chronic inflammatory liver disease, and its pathogenesis is not fully understood. Our previous study discovered that receptor interacting protein kinase 3 (RIP3) is correlated with serum transaminase l
Autor:
Luping Wang, Panxia Wang, Suowen Xu, Zhuoming Li, Dayue Darrel Duan, Jiantao Ye, Jingyan Li, Yanqing Ding, Wenqing Zhang, Jing Lu, Peiqing Liu
Publikováno v:
International Journal of Biological Sciences
Poly(ADP-ribosyl)ation (PARylation) and SUMO modification (SUMOylation) are novel post-translational modifications (PTMs) mainly induced by PARP1 and SUMO1. Growing evidence has revealed that C/EBPβ plays multiple roles in biological processes and p
Autor:
Feng, Qiushi, Yang, Panpan, Wang, He, Li, Congshan, Hasegawa, Tomoka, Liu, Zhaopeng, Li, Minqi
Publikováno v:
International Journal of Biological Sciences
Microtubules, a major target in oral squamous cell carcinoma (OSCC) chemotherapy, contribute to multiple malignant biological behaviors, including proliferation, migration, and epithelial-mesenchymal transition (EMT). Surpassing traditional tubulin i
Autor:
Pei-Ling, Chi, Chin-Chang, Cheng, Cheng-Chung, Hung, Mei-Tzu, Wang, Hsien-Yueh, Liu, Meng-Wei, Ke, Min-Ci, Shen, Kun-Chang, Lin, Shu-Hung, Kuo, Pin-Pen, Hsieh, Shue-Ren, Wann, Wei-Chun, Huang
Publikováno v:
International Journal of Biological Sciences
Pulmonary arterial hypertension (PAH) is characterized by muscularized pulmonary blood vessels, leading to right heart hypertrophy and cardiac failure. However, state-of-the-art therapeutics fail to target the ongoing remodeling process. Here, this s
Autor:
Yan-Ming, Liu, Yue, Cao, Ping-Sen, Zhao, Liang-Yin, Wu, Ya-Min, Lu, Yu-Long, Wang, Jia-Feng, Zhao, Xin-Guang, Liu
Publikováno v:
International Journal of Biological Sciences
Background: Circular RNAs (circRNAs), which generally act as microRNA (miRNA) sponges to competitively regulate the downstream target genes of miRNA, play an essential role in cancer biology. However, few studies have been reported on the role of cir
Autor:
Xiao Wang, Wei Huang, Shaoxiang Wang, Chunxia Hu, Ruiqin Cui, Qian Tang, Shumin Cheng, Shouxia Xie, Xinyou Wang, Shiyi Liu, Min Zhang, Yuying Peng, Ling Ou, Ruihuan Chai
Publikováno v:
International Journal of Biological Sciences
Esophageal carcinoma (EC) ranks sixth among cancers in mortality worldwide and effective drugs to reduce EC incidence and mortality are lacking. To explore potential anti-esophageal cancer drugs, we conducted drug screening and discovered that verdin
Autor:
Akimasa Seno, Fei Chen, Yao Fu, Yiran Qiu, Bandar Almutairy, Lingzhi Li, Wenxuan Zhang, Chitra Thakur, Priya Wadgaonkar, Zhuoyue Bi
Publikováno v:
International Journal of Biological Sciences
Accumulating evidence indicates a carcinogenic role of environmental arsenic exposure, but mechanisms on how arsenic fosters malignant transformation of the normal cells are not fully established. By applying untargeted global metabolomics approach,
Autor:
Xuewei Yan, Chao Yao, Cheng Fang, Min Han, Chenyuan Gong, Dan Hu, Weiming Shen, Lixin Wang, Suyun Li, Shiguo Zhu
Publikováno v:
International Journal of Biological Sciences
Background: Natural killer (NK) cell-based immunotherapy is clinically limited due to insufficient tumor infiltration in solid tumors. We have previously found that the natural product rocaglamide (RocA) can enhance NK cell-mediated killing of non-sm
Autor:
Wenzhen Gao, Minqi Li, Shanshan Liu, Rongjian Su, Tomoka Hasegawa, Juan Du, Qin Zhou, Yupu Lu
Publikováno v:
International Journal of Biological Sciences
Background: Oral squamous cell carcinoma (OSCC) refers to the malignant tumor of the head and neck with a highest morbidity. It exhibits a poor prognosis and unsatisfactory treatment, which is partially attributed to delayed diagnosis. As indicated f
Publikováno v:
International Journal of Biological Sciences
Simultaneous P53 loss and activation of the PTEN-restricted PI3K-AKT pathway frequently occur in aggressive breast cancers. P53 loss causes genome instability, while PTEN loss and/or activating mutations of PIK3CA and AKT promote cancer cell prolifer