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Autor:
Wenjing Pang, Xiangjun Meng, Yu Wang, Aisen Zhang, Lei Wang, Lei Li, Weiyan Yao, Xin Huang, Lidan Hou, Xin Dai
Publikováno v:
International Journal of Biological Sciences
New-onset diabetes mellitus has a rough correlation with pancreatic cancer (PaC), but the underlying mechanism remains unclear. This study aimed to explore the exosomal microRNAs and their potential role in PaC-induced β-cell dysfunction. The pancre
Autor:
Xicai Sun, Hongmeng Yu, Xiujuan Zhang, Xiaoyu Feng, Xuewen Li, Liujing Zhuang, Nan Jiang, Ping Wang, Rui Xu, Li Wang, Wenwen Ren, Yiqun Yu
Publikováno v:
Theranostics
Olfactory dysfunctions, including hyposmia and anosmia, affect ~100 million people around the world and the underlying causes are not fully understood. Degeneration of olfactory sensory neurons and incapacity of globose basal cells to generate olfact
Autor:
Jing Han, Xueqin Li, Xuejia Sang, Na Sun, Rongqin Li, Jing Yang, Jie Zhao, Takayuki Ikezoe, Xin Chen
Publikováno v:
International Journal of Biological Sciences
HLA-F, a nonclassical HLA class I molecule, is required for regulating immune tolerance. In recent years, HLA-F has been found to play a role in a variety of cancers, including glioma (GM). Additionally, high expression of HLA-F predicts the poor ove
Subpopulations of exosomes purified via different exosomal markers carry different microRNA contents
Autor:
Pao-Jen Kuo, Chia-Wei Lin, Ching-Hua Hsieh, Chia-Wen Tsai, Chia-Jung Wu, Shao-Chun Wu, Tsu-Hsiang Lu, Cheng-Shyuan Rau, Yi-Chan Wu
Publikováno v:
International Journal of Medical Sciences
The heterogeneity of exosome populations presents a great challenge to their study. The current study was designed to investigate the potential heterogeneity miRNA contents in circulating exosomes purified via different exosomal markers. In this stud
Autor:
Jianqun Han, Meicen Zhou, Ailing Li, Mingming Liu, Xiaochen Yuan, Xueting Liu, Bingwei Li, Wenbao Lu
Publikováno v:
International Journal of Biological Sciences
Tumor angiogenesis is an essential step in tumor growth and metastasis. The initiation of tumor angiogenesis is dictated by a shift in the balance between proangiogenic and antiangiogenic gene expression programs. Roquin2 is a zinc-finger RNA-binding
Publikováno v:
International Journal of Biological Sciences
Background: Autophagy regulates many cell functions related to cancer, ranging from cell proliferation and angiogenesis to metabolism. Due to the close relationship between autophagy and tumors, we investigated the predictive value of autophagy-relat
Autor:
So Young Kyung, Chunxue Jiang, Song Hee Lee, Su Hyun Lee, So Hyun Park, Jae Hyeon Park, Hyung Sik Kim, Amit Kundu, Ye Seul Kim
Publikováno v:
International Journal of Biological Sciences
Ovarian cancer is a common cause of death among gynecological cancers. Although ovarian cancer initially responds to chemotherapy, frequent recurrence in patients remains a therapeutic challenge. Pyruvate kinase M2 (PKM2) plays a pivotal role in regu
Autor:
Wenqiang Tang, Peiying Cai, Li Pan, Peng Li, Ke Li, Wei Liu, Anqi Zhang, Yiting Wang, Meng An, Cui Zhu, Li Wang, Min Meng, Bo Fu
Publikováno v:
International Journal of Biological Sciences
Circular RNAs (circRNAs) play critical roles in tumorigenesis and the progression of various cancers. We previously identified a novel upregulated circRNA, circBCBM1 (hsa_circ_0001944), in the context of breast cancer brain metastasis. However, the p
Autor:
Yu-Kai Huang, Liang-Chuan Lai, Yuh Pyng Sher, Ting Ting Kuo, Shih Ting Bai, Han Shui Hsu, Wei Chao Chang, Chen Yuan Lin, Guan Chin Tseng, Xing Guo Li, Wei-Chung Cheng, Yi Fan Jiang, Chih Ying Hsieh, Chia Chien Lo, Yu Sen Lin
Publikováno v:
International Journal of Biological Sciences
Hypoxia and angiogenesis play key roles in the pathogenesis of esophageal squamous cell carcinoma (ESCC), but regulators linking these two pathways to drive tumor progression remain elusive. Here we provide evidence of ADAM9's novel function in ESCC
Publikováno v:
International Journal of Biological Sciences
Background: This meta-analysis was aimed to quantitatively assess the associations of metabolic syndrome (MetS) and its components with colorectal cancer (CRC). Methods: PubMed, EMBASE and Web of Science databases were systematically searched for eli