Zobrazeno 51 - 60
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Autor:
Jing Wen, Jing Wu, Xia He, Mingyu Du, Lu-Xi Qian, Xinyu Hu, Jie Chen, Li Yin, Yan-Xin Fan, Fanyu Peng, Xuesong Jiang
Publikováno v:
International Journal of Biological Sciences
Nasopharyngeal carcinoma (NPC) is known for its potential to progress to the lymph nodes and distant metastases at an early stage. As an important regulator in tumorigenesis biological processes, the functions of lncRNA in NPC tumor development remai
Autor:
Pingfu Hou, Sufang Chu, Mei-Lin Shi, Tian Lin, Minle Li, Junnian Zheng, Tao Jiang, Jin Bai, Sen Meng, Fang Chen, Zhongwei Li
Publikováno v:
International Journal of Biological Sciences
Long non-coding RNAs (lncRNAs) play key roles in various human cancers. We aimed to determine the key lncRNAs mediating colorectal cancer (CRC) progression. We identified some lncRNAs aberrantly expressed in CRC tissues by using lncRNA microarrays an
Publikováno v:
International Journal of Biological Sciences
Suppression of type I interferon (IFN) response is one pathological outcome of the infection of highly pathogenic human coronaviruses. To effect this, severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 encode multiple IFN antagon
Autor:
Weisheng Luo, Wang Yifei, Ji Xiao, Lianzhou Huang, Xiaowei Song, Yuying Ma, Yiliang Wang, Ping Liu, Zhe Ren, Xiaohui Wang
Publikováno v:
International Journal of Medical Sciences
SARS-CoV-2 infection poses a global challenge to human health. Upon viral infection, host cells initiate the innate antiviral response, which primarily involves type I interferons (I-IFNs), to enable rapid elimination of the invading virus. Previous
Autor:
Bakhos A. Tannous, Jinhai Ye, Jiahuan Wu, Jun Gao, Chuan He, Ruyu Liang, Lei Cao, Huixin Zhang, Weiyan You, Tian Tian, Qing Ye
Publikováno v:
Theranostics
Ischemic stroke remains a major cause of death, and anti-inflammatory strategies hold great promise for preventing major brain injury during reperfusion. In the past decade, stem cell-derived extracellular vesicles (EVs) have emerged as novel therape
Autor:
Xiaohua Douglas Zhang, Runpei Lin, Hui Wang, Haisheng Hu, Mingshan Xue, Ning Li, Yifeng Zeng, Yingjie Zhen, Luqian Zhou, Hao Chen, Zhifeng Huang, Teng Zhang, Baoqing Sun
Publikováno v:
International Journal of Biological Sciences
Dysregulated immune response and abnormal repairment could cause secondary pulmonary fibrosis of varying severity in COVID-19, especially for the elders. The Krebs Von den Lungen-6 (KL-6) as a sensitive marker reflects the degree of fibrosis and this
Autor:
Kathy Qian Luo, Renfei Wu
Publikováno v:
International Journal of Biological Sciences
The COVID-19 pandemic has been raging worldwide for more than a year. Many efforts have been made to create vaccines and develop new antiviral drugs to cope with the disease. Here, we propose the application of short interfering RNAs (siRNAs) to degr
Autor:
Yefei Shi, Qing Yu, Mark W. Feinberg, Bo Li, Ming Zhai, Weixia Jian, Xu Xu, Peipei Luan, Shuangjie You, Wenhui Peng, Wenxin Kou, Jianhui Zhuang
Publikováno v:
Theranostics
Angiogenesis is a critical step in repair of tissue injury. The pattern recognition receptors (PRRs) recognize pathogen and damage associated molecular patterns (DAMPs) during injury and achieve host defense directly. However, the role of NLR family
Autor:
Minmin Deng, Jinwang Ye, Qiuzhi Zhou, Weijin Wang, Tao Jiang, Dan Ke, Xin Wang, Yanchao Liu, Jian-Zhi Wang, Qun Wang, Jie Zheng, Shihong Li, Yipeng Wang
Publikováno v:
Theranostics
Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the related tauopathies, thus targeting tau could be promising for drug development. Proteolysis Targeting Chimera (PROTAC) is a novel drug discovery strategy for
Autor:
David Gius, Angela E. Dean, Songhua Quan, Elizabeth L. Tran, Valerie Tokars, Yucheng Gao, Yueming Zhu
Publikováno v:
International Journal of Biological Sciences
Manganese superoxide dismutase (MnSOD) acetylation (Ac) has been shown to be a key post-translational modification important in the regulation of detoxification activity in various disease models. We have previously demonstrated that MnSOD lysine-68