Zobrazeno 1 - 10
of 111
pro vyhledávání: ''
Autor:
Feng, Qiushi, Yang, Panpan, Wang, He, Li, Congshan, Hasegawa, Tomoka, Liu, Zhaopeng, Li, Minqi
Publikováno v:
International Journal of Biological Sciences
Microtubules, a major target in oral squamous cell carcinoma (OSCC) chemotherapy, contribute to multiple malignant biological behaviors, including proliferation, migration, and epithelial-mesenchymal transition (EMT). Surpassing traditional tubulin i
Autor:
Yan-Ming, Liu, Yue, Cao, Ping-Sen, Zhao, Liang-Yin, Wu, Ya-Min, Lu, Yu-Long, Wang, Jia-Feng, Zhao, Xin-Guang, Liu
Publikováno v:
International Journal of Biological Sciences
Background: Circular RNAs (circRNAs), which generally act as microRNA (miRNA) sponges to competitively regulate the downstream target genes of miRNA, play an essential role in cancer biology. However, few studies have been reported on the role of cir
Autor:
Xiao Wang, Wei Huang, Shaoxiang Wang, Chunxia Hu, Ruiqin Cui, Qian Tang, Shumin Cheng, Shouxia Xie, Xinyou Wang, Shiyi Liu, Min Zhang, Yuying Peng, Ling Ou, Ruihuan Chai
Publikováno v:
International Journal of Biological Sciences
Esophageal carcinoma (EC) ranks sixth among cancers in mortality worldwide and effective drugs to reduce EC incidence and mortality are lacking. To explore potential anti-esophageal cancer drugs, we conducted drug screening and discovered that verdin
Autor:
Wenzhen Gao, Minqi Li, Shanshan Liu, Rongjian Su, Tomoka Hasegawa, Juan Du, Qin Zhou, Yupu Lu
Publikováno v:
International Journal of Biological Sciences
Background: Oral squamous cell carcinoma (OSCC) refers to the malignant tumor of the head and neck with a highest morbidity. It exhibits a poor prognosis and unsatisfactory treatment, which is partially attributed to delayed diagnosis. As indicated f
Autor:
Qingwei Meng, Yongxu Zhou, Jianxiong Geng, Bo Pan, Lishuang Qi, Yan Yu, Yingyue Cao, Zijie Wang, Xin Wang, Zixin Wei, Shi Jin, Yaoguo Lang, Shanqi Xu
Publikováno v:
International Journal of Biological Sciences
RNA-binding motif protein 10 (RBM10), one of the members of the RNA-binding protein (RBP) family, has a tumor suppressor role in multiple cancers. However, the functional role of RBM10 in lung adenocarcinoma (LUAD) and the underlying molecular mechan
Autor:
Deng Yuezhen, Zeng Zimei, Nie Yingjie, Li Yingzi, Li Zhi, Liu Guanxin, Cao Zhen, Mu Yun, Zhou Chengzhi, Chen Tao, Gao Jie, Sun Lunquan
Publikováno v:
International Journal of Biological Sciences
Resistance to radiotherapy is frequently observed in the clinic and leads to poor prognosis of non-small cell lung cancer (NSCLC). How to overcome resistance to radiotherapy is a challenge in the treatment of NSCLC. In this study, PPDPF was found to
Autor:
Nour Al-Jabi, Amjad Ali, Khuloud Bajbouj, Rola Abu Jabal, Hema Unnikannan, Jasmin Shafarin, Jibran Sualeh Muhammad, Mawieh Hamad
Publikováno v:
International Journal of Biological Sciences
BET bromodomain BRD4 and RAC1 oncogenes are considered important therapeutic targets for cancer and play key roles in tumorigenesis, survival and metastasis. However, combined inhibition of BRD4-RAC1 signaling pathways in different molecular subtypes
Publikováno v:
International Journal of Biological Sciences
Rutin, the main component of Potentilla discolor Bunge, was proven to exhibit anti-tumor properties. Sorafenib (SO) is conventionally used in chemotherapy against hepatocellular carcinoma (HCC), but acquired resistance developed during long-term ther
Autor:
Koichiro Wada, Jingkai Sun, Motoo Araki, Masami Watanabe, Naijin Xu, Abai Xu, Peng Huang, Wenfeng Lin, Yasutomo Nasu, Takuya Sadahira, Chunxiao Liu
Publikováno v:
International Journal of Biological Sciences
Repeated cycles of first-line chemotherapy drugs such as doxorubicin (DOX) and cisplatin (CIS) trigger frequent chemoresistance in recurrent urothelial bladder cancer (UBC). Nitroxoline (NTX), an antibiotic to treat urinary tract infections, has been
Publikováno v:
International Journal of Biological Sciences
Background: Esophageal cancer is the sixth-most common fatal malignant tumor worldwide. Little is known regarding the genetic drivers that influence targeted therapy outcomes in patients with esophageal cancer. Exploring the pathogenesis of this leth