Zobrazeno 1 - 10
of 106
pro vyhledávání: ''
Autor:
Nour Al-Jabi, Amjad Ali, Khuloud Bajbouj, Rola Abu Jabal, Hema Unnikannan, Jasmin Shafarin, Jibran Sualeh Muhammad, Mawieh Hamad
Publikováno v:
International Journal of Biological Sciences
BET bromodomain BRD4 and RAC1 oncogenes are considered important therapeutic targets for cancer and play key roles in tumorigenesis, survival and metastasis. However, combined inhibition of BRD4-RAC1 signaling pathways in different molecular subtypes
Publikováno v:
International Journal of Biological Sciences
Long non-coding RNAs (lncRNAs) are a series of non-coding RNAs that lack open reading frameworks. Accumulating evidence suggests important roles for lncRNAs in various diseases, including cancers. Recently, lncRNA H19 (H19) became a research focus du
Autor:
Jing Wen, Jing Wu, Xia He, Mingyu Du, Lu-Xi Qian, Xinyu Hu, Jie Chen, Li Yin, Yan-Xin Fan, Fanyu Peng, Xuesong Jiang
Publikováno v:
International Journal of Biological Sciences
Nasopharyngeal carcinoma (NPC) is known for its potential to progress to the lymph nodes and distant metastases at an early stage. As an important regulator in tumorigenesis biological processes, the functions of lncRNA in NPC tumor development remai
Autor:
Pingfu Hou, Sufang Chu, Mei-Lin Shi, Tian Lin, Minle Li, Junnian Zheng, Tao Jiang, Jin Bai, Sen Meng, Fang Chen, Zhongwei Li
Publikováno v:
International Journal of Biological Sciences
Long non-coding RNAs (lncRNAs) play key roles in various human cancers. We aimed to determine the key lncRNAs mediating colorectal cancer (CRC) progression. We identified some lncRNAs aberrantly expressed in CRC tissues by using lncRNA microarrays an
Autor:
Yi Chen, Tung-Ying Chen, Yaxuan Liu, Jiwei Gao, Shuijie Li, Wen-Kuan Huang, Chun-Nan Yeh, Huafang Su
Publikováno v:
International Journal of Biological Sciences. 17:1808-1820
Increasing evidence reveals that the Rho GTPase-activating protein is a crucial negative regulator of Rho family GTPase involved in tumorigenesis. The Rho GTPase-activating protein 25 (ARHGAP25) has been shown to specifically inactivate the Rho famil
Publikováno v:
International Journal of Biological Sciences
Membrane-associated ring-CH-type finger (MARCH) proteins belong to the E3 ubiquitin ligase family, which regulates protein stability by increasing ubiquitination. Recent evidence has shown that some MARCH proteins play important roles in cancer devel
Autor:
Jing Han, Xueqin Li, Xuejia Sang, Na Sun, Rongqin Li, Jing Yang, Jie Zhao, Takayuki Ikezoe, Xin Chen
Publikováno v:
International Journal of Biological Sciences
HLA-F, a nonclassical HLA class I molecule, is required for regulating immune tolerance. In recent years, HLA-F has been found to play a role in a variety of cancers, including glioma (GM). Additionally, high expression of HLA-F predicts the poor ove
Autor:
Jia Cheng, Jingjing Hou, Zhijun Hong, Huiqin Zhuo, Jiabao Zhao, Xin Chen, Lin Wang, Jianchun Cai, Wei Zheng
Publikováno v:
International Journal of Biological Sciences
Gastric Cancer (GC) is one of the main causes leading to death. PMP22, as a member of the GAS3 family of tetraspan proteins, it is associated with a variety of neurological diseases. Recently, more and more studies have shown that PMP22 play a great
Publikováno v:
International Journal of Biological Sciences. 17:1613-1628
The treatment of advanced prostate cancer, castration-resistant prostate cancer, remains challenging. The mechanisms of action of ATP binding cassette subfamily C member 5 (ABCC5) in prostate cancer and its relationship with drug resistance are still
Autor:
Wenbing Liu, Zichen Huang, Yiqun Jiang, Hua He, Li Xie, Jin Wang, Chao Chen, Jingjing Huang, Yongguang Tao, Sufang Wu, Li Cong
Publikováno v:
International Journal of Biological Sciences
Abnormal lipid metabolism including synthesis, uptake, modification, degradation and transport has been considered a hallmark of malignant tumors and contributes to the supply of substances and energy for rapid cell growth. Meanwhile, abnormal lipid