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Autor:
Koichiro Wada, Jingkai Sun, Motoo Araki, Masami Watanabe, Naijin Xu, Abai Xu, Peng Huang, Wenfeng Lin, Yasutomo Nasu, Takuya Sadahira, Chunxiao Liu
Publikováno v:
International Journal of Biological Sciences
Repeated cycles of first-line chemotherapy drugs such as doxorubicin (DOX) and cisplatin (CIS) trigger frequent chemoresistance in recurrent urothelial bladder cancer (UBC). Nitroxoline (NTX), an antibiotic to treat urinary tract infections, has been
Publikováno v:
International Journal of Biological Sciences
Mammalian target of rapamycin (mTOR) is one of the most commonly activated pathways in human cancers, including lung cancer. Targeting mTOR with molecule inhibitors is considered as a useful therapeutic strategy. However, the results obtained from th
Publikováno v:
International Journal of Biological Sciences
Breast cancer susceptibility gene 1 (BRCA1) encodes a tumor suppressor that is frequently mutated in familial breast and ovarian cancer patients. BRCA1 functions in multiple important cellular processes including DNA damage repair, cell cycle checkpo
Autor:
Jia Cheng, Jingjing Hou, Zhijun Hong, Huiqin Zhuo, Jiabao Zhao, Xin Chen, Lin Wang, Jianchun Cai, Wei Zheng
Publikováno v:
International Journal of Biological Sciences
Gastric Cancer (GC) is one of the main causes leading to death. PMP22, as a member of the GAS3 family of tetraspan proteins, it is associated with a variety of neurological diseases. Recently, more and more studies have shown that PMP22 play a great
Autor:
Janire Prieto-Elordui, Mikel Azkargorta, Esperanza Gonzalez, Felix Elortza, Clara Garcia-Vallicrosa, Sonia Blanco-Sampascual, Juan M. Falcón-Pérez
Publikováno v:
International Journal of Biological Sciences
Alcohol abuse has a high impact on the mortality and morbidity related to a great number of diseases and is responsible for the development of alcoholic liver disease (ALD). It remains challenging to detect and evaluate its severity, which is crucial
Publikováno v:
International Journal of Biological Sciences
Mechanisms of breast cancer progression and invasion, often involve alteration of hormonal signaling, and upregulation and/or activation of signal transduction pathways that input to cell cycle regulation. Herein, we describe a rationally designed fi
Publikováno v:
International Journal of Medical Sciences
The anatomical positions of pelvic floor organs are maintained mainly by ligaments and muscles. Long-term excessive mechanical tension stimulation of pelvic floor tissue beyond the endurance of ligaments or muscles will lead to the occurrence of pelv
Autor:
Miyako Shimasaki, Shusuke Ueda, Norio Kawahara, Yoshimichi Ueda, Hiroaki Hirata, Toru Ichiseki
Publikováno v:
International Journal of Medical Sciences
The main precipitant of glucocorticoid-associated femoral head osteonecrosis is widely accepted to be an ischemic-hypoxic event, with oxidative stress also as an underlying factor. Mitochondrial DNA is more vulnerable to oxidative injury than the nuc
Publikováno v:
International Journal of Medical Sciences
Diabetes-mediated hyperglycemia is a major risk factor for renal fibrosis, resulting in the development of chronic kidney diseases. To address this issue, the effect of melatonin, which has an antioxidative potential, on renal fibrosis in human renal
Publikováno v:
International Journal of Medical Sciences
Oxidative stress has been linked to senescence and tumorigenesis via modulation of the cell cycle. Using a hydrogen peroxide (H2O2)-induced oxidative stress-induced premature senescence (OSIPS) model previously reported by our group, this study aimed