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pro vyhledávání: ''
Autor:
Jay Patel, Victoria P. Werth, Adarsh Ravishankar, Thomas Vazquez, Yubin Li, Madison Grinnell, DeAnna Diaz, Christina E. Bax, Muhammad M. Bashir
Publikováno v:
Theranostics
Objectives: Extracellular vesicles (EVs) are lipid bilayer membrane vesicles that are present in various bodily fluids and have been implicated in autoimmune disease pathogenesis. Type I interferons (IFN), specifically IFN-β, are uniquely elevated i
Autor:
Yefei Shi, Qing Yu, Mark W. Feinberg, Bo Li, Ming Zhai, Weixia Jian, Xu Xu, Peipei Luan, Shuangjie You, Wenhui Peng, Wenxin Kou, Jianhui Zhuang
Publikováno v:
Theranostics
Angiogenesis is a critical step in repair of tissue injury. The pattern recognition receptors (PRRs) recognize pathogen and damage associated molecular patterns (DAMPs) during injury and achieve host defense directly. However, the role of NLR family
Autor:
Giuseppina Milano, Edoardo Lazzarini, Tudor Emanuel Fertig, Dario Di Silvestre, Lucio Barile, Fumihiro Sanada, Carolina Balbi, Yoshiaki Taniyama, Thomas F. Lüscher, Pierluigi Mauri, Giuseppe Vassalli, Sara Bolis, Mihaela Gherghiceanu
Publikováno v:
Theranostics
Although a small number of cardiomyocytes may reenter the cell cycle after injury, the adult mammalian heart is incapable of a robust cardiomyocyte proliferation. Periostin, a secreted extracellular matrix protein, has been implicated as a regulator
Autor:
Jun Ni, Junling Liu, Bing Su, Qiang Zou, Xian Huang, Zhiduo Liu, Wen Yang, Yuexiao Tao, Samina Shaheen, Yufeng Yao, Xiao Dong Yang, Jinnan Yue, Hongrui Xiang, Chenyang Guan, Jun Tu, Zhaoyuan Hou, Xuefeng Wu, Zhenyan Jiang, Zhenshan Liu, Jinke Cheng
Publikováno v:
Theranostics
Salmonella typhimurium (S. typhimurium) infection of macrophage induces NLRC4 inflammasome-mediated production of the pro-inflammatory cytokines IL-1β. Post-translational modifications on NLRC4 are critical for its activation. Sirtuin3 (SIRT3) is th
Autor:
Manqi Gao, Meixi Yu, Shuainan Li, Fan Yang, Hong Lei, Baofeng Yang, Xiaofei Guo, Yang Yu, Wenya Ma, Shenzhen Liu, Wenwen Zhang, Rui Gong, Ruijie Song, Naufal Zagidullin, Xiuxiu Wang, Benzhi Cai, Natalia Sukhareva, Djibril Bamba, Juan Xu, Yiming Zhao, Zhenwei Pan, Zhenbo Han, Binbin Xu, Yang Cao, Zihang Xu, Ying Yu, Xingda Li, Yan Xu, Ying Zhang
Publikováno v:
Theranostics
N6-methyladenosine (m6A) RNA modification, a dynamic and reversible process, is essential for tissue development and pathogenesis. However, the potential involvement of m6A in the regulation of cardiomyocyte (CM) proliferation and cardiac regeneratio
Autor:
Xicai Sun, Hongmeng Yu, Xiujuan Zhang, Xiaoyu Feng, Xuewen Li, Liujing Zhuang, Nan Jiang, Ping Wang, Rui Xu, Li Wang, Wenwen Ren, Yiqun Yu
Publikováno v:
Theranostics
Olfactory dysfunctions, including hyposmia and anosmia, affect ~100 million people around the world and the underlying causes are not fully understood. Degeneration of olfactory sensory neurons and incapacity of globose basal cells to generate olfact
Autor:
Tatjana Dorn, Thomas Seidel, Xiaochun Cao-Ehlker, Aarif M. N. Batcha, Marie Semmler, Christine M. Schneider, Roland Tomasi, Alessandra Moretti, Tilmann Volk, Kun Lu, Andreas Dendorfer
Publikováno v:
Theranostics
Bio-engineered myocardium has great potential to substitute damaged myocardium and for studies of myocardial physiology and disease, but structural and functional immaturity still implies limitations. Current protocols of engineered heart tissue (EHT
Publikováno v:
Theranostics
Extracellular vesicles (EVs) are nanoscale extracellular vesicles derived from endocytosis that are crucial to intercellular communication. EVs possess natural biocompatibility and stability that allow them to cross biological membranes and that prot
Autor:
Yongjiang Zheng, Yueyuan Feng, Jinheng Wang, Zhimin Du, Hui Zhang, Yujun Qi, Jinbao Liu, Chenggong Tu
Publikováno v:
Theranostics
Extracellular vesicles (EVs), including exosomes and microvesicles, derived from bone marrow stromal cells (BMSCs) have been demonstrated as key factors in the progression and drug resistance of multiple myeloma (MM). EV uptake involves a variety of
Autor:
Yi Ning Cheng, Chih Hsing Wu, Kuo Ting Lee, Ching Chun Yang, Pei Jane Tsai, Yau Sheng Tsai, Ta Chun Lin, Chin Sung Chang
Publikováno v:
Theranostics
Rationale: Stimulation of the NLRP3 inflammasome by metabolic byproducts is known to result in inflammatory responses and metabolic diseases. However, how the host controls aberrant NLRP3 inflammasome activation remains unclear. PPARγ, a known regul