Zobrazeno 91 - 100
of 339
pro vyhledávání: ''
Autor:
Di Wang, Baohua Liu, Zhuojing Luo, Liu Yang, Chao Zheng, Pengzhen Cheng, Bo Gao, Jing Fan, Xiaolong Xu
Publikováno v:
Theranostics
Progerin, a truncated unprocessed lamin A protein, causes tissue aging and degeneration. In this study we explored the role of progerin in the pathogenesis of intervertebral disc degeneration (IDD). We also examined the effect of sulforaphane (SFN) o
Autor:
Sijun Hu, Yi Wen, Zuolin Jin, Hongxu Yang, Junjie Wu, Yuxing Zhang, Ding Bai, Axian Wang, Xiao Dong Chen
Publikováno v:
Theranostics
Periodontal ligament stem cells (PDLSCs) can repair alveolar bone defects in periodontitis in a microenvironment context-dependent manner. This study aimed to determine whether different extracellular matrices (ECMs) exert diverse effects on osteogen
Autor:
Weiwei Zhang, Jiuxuan Li, Qian Ran, Fengjie Li, Lixin Xiang, Yang Xiang, Li Chen, Chun Wu, Xiaomei Zhang, Zhongjun Li, Jiang Wu
Publikováno v:
Theranostics
Irradiation can greatly inhibit osteogenesis of bone marrow mesenchymal stem cells (BM-MSCs). However, the mechanism remains unclear. Methods: We analyzed the expression profile of long noncoding RNAs (lncRNAs) in BM-MSCs using microarray data. LncRN
Autor:
Ming Yin, Zhenchuan Miao, Jinyan Feng, Guang Yang, Yunxia Liu, Haolin Yun, Xijun Song, Jun-qi Niu, Ying Yuan, Hongfeng Yuan, Man Zhao, Zixian Liu, Lei Liu, Xiaodong Zhang, Zhongqing Lin, Mingming Sun, Yanan Bu
Publikováno v:
Theranostics
Rationale: Hepatitis B virus (HBV) is a leading cause of liver diseases. HBV covalently closed circular DNA (cccDNA) is a critical obstacle of complete elimination by anti-HBV therapy. HBV cccDNA accumulates in nucleus as a chromatin-like cccDNA mini
Autor:
Eugeny A. Ermilov, Annegret Preuß, Tilo Knape, Steffen Hackbarth, Tobias Bornhütter, Beate Röder, Michael Schindler, Laura Kuchler, Sandra Gunne, Bernhard Brüne, Verena Trümper, Lázló Ujlaky-Nagy, Michael J. Parnham, Andreas von Knethen, Anne Schäfer, György Vereb
Publikováno v:
Theranostics
PPARγ is a pharmacological target in inflammatory and metabolic diseases. Upon agonistic treatment or following antagonism, binding of co-factors is altered, which consequently affects PPARγ-dependent transactivation as well as its DNA-independent
Autor:
Yijun Hu, Shanrong Liu, Chuanbin Mao, Liang Chen, Fang Zhang, Zaixin Zhou, Kai Cheng, Shupeng Liu, Dandan Zhang
Publikováno v:
Theranostics
Producing keratinocyte cells (KCs) in large scale is difficult due to their slow proliferation, disabling their use as seed cells for skin regeneration and wound healing. Cell reprogramming is a promising inducer-based approach to KC production but o
Autor:
Shu Guan, Feng Jin, Miao He, Jing Zhang, Haishan Zhao, Mengtao Ma, Qiuchen Chen, Yuanyuan Yan, Zhaojin Yu, Mingli Sun, Qian Jiang, Weifan Yao, Minjie Wei
Publikováno v:
International Journal of Biological Sciences
Tumor metastasis is a complex and multistep process and its exact molecular mechanisms remain unclear. We attempted to find novel microRNAs (miRNAs) contributing to the migration and invasion of breast cancer cells. In this study, we found that the e
Publikováno v:
International Journal of Biological Sciences
Hypoxia is the most common characteristic of solid tumours driving cancer metastasis. Cancer cells release exosomes with various functions into the tumour microenvironment during cancer progression. However, the roles and associated mechanisms of hyp
Autor:
Ying Wang, Yan Li, Zeyu Liu, Xiao Song, Xiaoping Qian, Yu Zhang, Yutian Zheng, Xuewen Pang, Yanhui Yin
Publikováno v:
International Journal of Medical Sciences
Cancer-testis antigen MAGEA3, being restrictedly expressed in testis and various kinds of tumors, has long been considered as an ideal target for immunotherapy. In this study, we report that MAGEA3 interacts with STAT1 and regulates the expression of
Publikováno v:
International Journal of Biological Sciences
While neutrophils have dutifully performed their function in injury and infection, the recent works have found that cytotoxicity and/or cytostatic of neutrophils has also been observed in tumor. Till now the molecular players that participate in this