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pro vyhledávání: ''
Autor:
Sun-Hwa Kim, Keun Hur, Yu-Bin Lee, Nanda Maya Mali, Young-Jin Youn, Sung-Wook Nam, Dong-Keun Song, Chang-Won Hong, S.H. Lee, Hee Kyung Jin, Jee Hyun Lee, Jae-sung Bae, Jun-Kyu Kim, Sanjeeb Shrestha
Publikováno v:
Theranostics
Aims: Extracellular vesicles (EVs) are membrane-derived vesicles that mediate intercellular communications. Neutrophils produce different subtypes of EVs during inflammatory responses. Neutrophil-derived trails (NDTRs) are generated by neutrophils mi
Autor:
Si Liu, Xi Chen, Jinghai Chen, Lin Cai, Jianqiu Pei, Shengshou Hu, Xiangfeng Cong, Fang Wang, Xiaoxuan Dong, Ning Liu, Jerold Chun, Tian Liang
Publikováno v:
Theranostics
Background: Lysophosphatidic acid (LPA) is a small glycerophospholipid that acts as a potent extracellular signal in various biological processes and diseases. Our previous work demonstrated that the expression of the LPA receptors LPA1 and LPA3 is e
Emerging role of mTOR in tumor immune contexture: Impact on chemokine-related immune cells migration
Autor:
Qijie Zhao, Jing Jin
Publikováno v:
Theranostics
During the last few decades, cell-based anti-tumor immunotherapy emerged and it has provided us with a large amount of knowledge. Upon chemokines recognition, immune cells undergo rapid trafficking and activation in disease milieu, with immune cells
Autor:
Shengnan Yang, Ting Jiang, Jian Xiao, Yanqing Wu, Yuqin Mao, Xiaokun Li, Yiyang Li, Rui Li, Libing Ye, Duohui Li, Yuan Yuan, Chengbiao Wu, Hongyu Zhang, Jian Wang, Ling Xie
Publikováno v:
Theranostics
Rationale: Autophagy in Schwann cells (SCs) is crucial for myelin debris degradation and clearance following peripheral nerve injury (PNI). Nerve growth factor (NGF) plays an important role in reconstructing peripheral nerve fibers and promoting axon
Autor:
Zhilong Liu, Qing Luo, Guanbin Song, Lei Li, Jieping Chen, Yongxiu Huang, Yu Hou, Weiru Wu, Li Yang, Zhe Chen
Publikováno v:
Theranostics
Background and Purpose: The exhaustion of muscle satellite cells (SCs) is correlated with muscle diseases, including sarcopenia and Duchenne muscular dystrophy. Exercise benefits skeletal muscle homeostasis and promotes proliferation of SCs. Elucidat
Autor:
Zhongchao Han, Jia Xu, Lingling Wang, Deling Kong, Zongjin Li, Qian Ji, Na Liu, Yan Zhang, Siying Liu, Kaiyue Zhang, Meikuang Lim, Kaige Cui, Shuang Zhao
Publikováno v:
Theranostics
Background: Embryonic stem cells (ES) have a great potential for cell-based therapies in a regenerative medicine. However, the ethical and safety issues limit its clinical application. ES-derived extracellular vesicles (ES-EVs) have been reported sup
Autor:
Lin Zhou, Xiaode Feng, Jingbang Wu, Shusen Zheng, Bin He, Yanpeng Zhang, Diyu Chen, Xiaoqian Zhang, Haiyang Xie, Jian Wu, Longfei Dai
Publikováno v:
International Journal of Biological Sciences
The high activity of Histone deacetylases (HDACs) in hepatocellular carcinoma (HCC) usually positively correlates with poor prognosis of patients. Accordingly histone deacetylases inhibitors (HDACis) are considered to be potential agents treating pat
Publikováno v:
International Journal of Biological Sciences
CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways, including PI3K/AKT, Rho GTPases and the R
Publikováno v:
International Journal of Biological Sciences
Purpose: Small cell lung cancer (SCLC) is highly lethal with no effective therapy. Wee1 kinase inhibitor AZD1775 (MK-1775) and mTOR kinase inhibitor MLN0128 (TAK228) are in clinical trials for relapsed SCLC and recurrent lung cancer, respectively. Ho
Autor:
Huijun Yu, Jingchun Guo, Xiaxia Zhu, Zhi Pang, Wei Zhou, Yi Xu, Wenxiang Wei, Jian Shen, Yuan Ji
Publikováno v:
International Journal of Biological Sciences
The Elongator is a complex with multiple subunits (Elp1-Elp6) which promotes transcript elongation and protein translation. In this study, we investigated the effects of Elongator on the migration and invasion of HCC cells as well as the underlying m