Zobrazeno 1 - 10
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pro vyhledávání: ''
Autor:
Shu Guan, Feng Jin, Miao He, Jing Zhang, Haishan Zhao, Mengtao Ma, Qiuchen Chen, Yuanyuan Yan, Zhaojin Yu, Mingli Sun, Qian Jiang, Weifan Yao, Minjie Wei
Publikováno v:
International Journal of Biological Sciences
Tumor metastasis is a complex and multistep process and its exact molecular mechanisms remain unclear. We attempted to find novel microRNAs (miRNAs) contributing to the migration and invasion of breast cancer cells. In this study, we found that the e
Publikováno v:
International Journal of Biological Sciences
Hypoxia is the most common characteristic of solid tumours driving cancer metastasis. Cancer cells release exosomes with various functions into the tumour microenvironment during cancer progression. However, the roles and associated mechanisms of hyp
Publikováno v:
International Journal of Biological Sciences
While neutrophils have dutifully performed their function in injury and infection, the recent works have found that cytotoxicity and/or cytostatic of neutrophils has also been observed in tumor. Till now the molecular players that participate in this
Autor:
Lin Zhou, Xiaode Feng, Jingbang Wu, Shusen Zheng, Bin He, Yanpeng Zhang, Diyu Chen, Xiaoqian Zhang, Haiyang Xie, Jian Wu, Longfei Dai
Publikováno v:
International Journal of Biological Sciences
The high activity of Histone deacetylases (HDACs) in hepatocellular carcinoma (HCC) usually positively correlates with poor prognosis of patients. Accordingly histone deacetylases inhibitors (HDACis) are considered to be potential agents treating pat
Autor:
Hua Hui Li, Li Fu, Stephen J. Meltzer, Yan Song Wang, Yuriko Mori, Xin Yuan Guan, Jingyi Sheng, Tu Xiong Huang, Ji Xian Xiong, Di Xiang, Binbin Tan, Yan Ru Qin, Jiao Yang, Cui Mian Zeng
Publikováno v:
International Journal of Biological Sciences
Esophageal squamous cell carcinoma (ESCC) occurs with the highest frequency in China, especially in the high-risk Northern Chinese. Recent studies have reported that SLC22A3 is significantly downregulated in non-tumor (NT) esophageal tissues from fam
Publikováno v:
International Journal of Biological Sciences
Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic conditions. This review discusses specific markers and origin of cardiac
Autor:
Xiangsheng Cai, Dianpeng Zheng, Shangliang Chen, She Miaoqin, Xu Xiaosong, Jingjing Li, Yang Xiaorong, Jianbin Zhu, Jinlong Li, Chen Shaolian, Huiying Chen, Xinglu Chen, Hongwei Li, Ruiying Li, Liu Jun, Mingyu Xu
Publikováno v:
International Journal of Biological Sciences
Endothelial dysfunction and excessively stimulated autophagy, often caused by oxidant injury or inflammation, will lead to atherosclerosis development and progression in diabetes. The aim of this study is to investigate the protective effect of gluca
Publikováno v:
International Journal of Biological Sciences
Purpose: Small cell lung cancer (SCLC) is highly lethal with no effective therapy. Wee1 kinase inhibitor AZD1775 (MK-1775) and mTOR kinase inhibitor MLN0128 (TAK228) are in clinical trials for relapsed SCLC and recurrent lung cancer, respectively. Ho
Autor:
Zhenhong Ni, Quan Wang, Huabing Qi, Ying Zhu, Liang Kuang, Lin Chen, Yangli Xie, Nan Su, Qiaoyan Tan, Min Jin, Hangang Chen, Yuanqiang Wang, Zuqiang Wang, Wanling Jiang, Xiaolan Du, Zhifeng Huang, Can Li, Chu-Xia Deng
Publikováno v:
International Journal of Biological Sciences
It has been reported that overactivation of fibroblast growth factor receptor 1 (FGFR1) is an important characteristic found in most non-small cell lung cancer (NSCLC) samples. Here, we identified a FGFR1 inhibitory peptide R1-P2 and investigated its
Publikováno v:
International Journal of Biological Sciences
The characteristic of carcinoma is cell migration and invasion, which involve in strong actin dynamics. Regulations of actin dynamics have been implicated in cancer cell migration and tumor progression. WDR1 (WD-repeat domain 1) is a major cofactor o