Zobrazeno 1 - 10
of 87
pro vyhledávání: ''
Autor:
Yefei Shi, Qing Yu, Mark W. Feinberg, Bo Li, Ming Zhai, Weixia Jian, Xu Xu, Peipei Luan, Shuangjie You, Wenhui Peng, Wenxin Kou, Jianhui Zhuang
Publikováno v:
Theranostics
Angiogenesis is a critical step in repair of tissue injury. The pattern recognition receptors (PRRs) recognize pathogen and damage associated molecular patterns (DAMPs) during injury and achieve host defense directly. However, the role of NLR family
Autor:
Manqi Gao, Meixi Yu, Shuainan Li, Fan Yang, Hong Lei, Baofeng Yang, Xiaofei Guo, Yang Yu, Wenya Ma, Shenzhen Liu, Wenwen Zhang, Rui Gong, Ruijie Song, Naufal Zagidullin, Xiuxiu Wang, Benzhi Cai, Natalia Sukhareva, Djibril Bamba, Juan Xu, Yiming Zhao, Zhenwei Pan, Zhenbo Han, Binbin Xu, Yang Cao, Zihang Xu, Ying Yu, Xingda Li, Yan Xu, Ying Zhang
Publikováno v:
Theranostics
N6-methyladenosine (m6A) RNA modification, a dynamic and reversible process, is essential for tissue development and pathogenesis. However, the potential involvement of m6A in the regulation of cardiomyocyte (CM) proliferation and cardiac regeneratio
Autor:
Yongjiang Zheng, Yueyuan Feng, Jinheng Wang, Zhimin Du, Hui Zhang, Yujun Qi, Jinbao Liu, Chenggong Tu
Publikováno v:
Theranostics
Extracellular vesicles (EVs), including exosomes and microvesicles, derived from bone marrow stromal cells (BMSCs) have been demonstrated as key factors in the progression and drug resistance of multiple myeloma (MM). EV uptake involves a variety of
Autor:
María Gómez-Serrano, Andrea Nist, Silke Reinartz, Annika Unger, Tim Bieringer, Raimund Dietze, Viviane Ponath, Sabine Müller-Brüsselbach, Elke Pogge von Strandmann, Mohamad K Hammoud, Christian Preußer, Johannes Graumann, Thorsten Stiewe, Anna M. Sokol, Florian Finkernagel, Rolf Müller
Publikováno v:
Theranostics
Arachidonic acid (AA) is a polyunsaturated fatty acid present at high concentrations in the ovarian cancer (OC) microenvironment and associated with a poor clinical outcome. In the present study, we have unraveled a potential link between AA and macr
Autor:
Yang Zhang, Jiucun Wang, Fuchu He, Yuanyuan Zhao, Li Jin, Yan Jiang, Liyan Wang, Chan Xiang, Fan Zhong, Haijian Wang, Chen Ding
Publikováno v:
Theranostics
Rationale: As the central hallmark of liver fibrosis, transdifferentiation of hepatic stellate cells (HSCs), the predominant contributor to fibrogenic hepatic myofibroblast responsible for extracellular matrix (ECM) deposition, is characterized with
Autor:
Tao Ye, Xiaoqi Yang, Kehua Jiang, Xiaoliang Wu, Peng Lv, Zhangqun Ye, Ejun Peng, Huan Yang, Chen Duan, Zhiqiang Chen, Kun Tang, Haoran Liu, Hongyan Lu, Ding Xia, Jianhe Liu
Publikováno v:
Theranostics
Calcium oxalate (CaOx) crystal can trigger kidney injury, which contributes to the pathogenesis of nephrocalcinosis. The phenotypes of infiltrating macrophage may impact CaOx-mediated kidney inflammatory injury as well as crystal deposition. How aryl
Autor:
Jie Yang, Kai Zhang, Shuai Ma, Jiao Zhao, Shanshan Tian, Liyuan Bi, Cheng Cao, Zhang Qi, Kaiwen Bao, Nan Song, Zhi Yao, Qian Wang, Wenchen Gong, Lei Shi, Yuejiao Wang, Ling Liu
Publikováno v:
Theranostics
Rationale: A number of guanine nucleotide exchange factors (GEFs) including epithelial cell transforming factor ECT2 are believed to drive carcinogenesis through activating distinct oncogenic GTPases. Yet, whether GEF-independent activity of ECT2 als
Publikováno v:
Theranostics
Rationale: Fructose-1, 6-bisphosphatase 1 (FBP1), a rate-limiting enzyme in gluconeogenesis, was recently shown to be a tumor suppressor and could mediate the activities of multiple transcriptional factors via its non-canonical functions. However, th
Autor:
Xuebin Qin, Zhongnan Qin, Jiayi Chen, Dechun Feng, Fengming Liu, Jinyan Zhang, Wen-Xing Ding, Yong Ji, Shen Dai
Publikováno v:
Theranostics
Rationale: Kupffer cells (KCs) play a crucial role in liver immune homeostasis through interacting with other immune cells and liver sinusoidal endothelial cells (LSECs). However, how KCs exactly interact with these cells for maintaining the homeosta
Endothelial cells produce angiocrine factors to regulate bone and cartilage via versatile mechanisms
Publikováno v:
Theranostics
Blood vessels are conduits distributed throughout the body, supporting tissue growth and homeostasis by the transport of cells, oxygen and nutrients. Endothelial cells (ECs) form the linings of the blood vessels, and together with pericytes, are esse