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Autor:
George Perry, Amber M Smith, Luwen Wang, Mengyu Liu, Jingjing Liang, Hisashi Fujioka, Xinglong Wang, Ju Gao
Publikováno v:
J Alzheimers Dis
Background: Abnormalities of mitochondrial fission and fusion, dynamic processes known to be essential for various aspects of mitochondrial function, have repeatedly been reported to be altered in Alzheimer’s disease (AD). Neurofibrillary tangles a
Publikováno v:
J Alzheimers Dis
Background: The vacuolar protein sorting 35 (VPS35) is the main component of the retromer recognition core complex system which regulates intracellular cargo protein sorting and trafficking. Downregulation of VPS35 has been linked to the pathogenesis
Publikováno v:
Cancer Biomarkers. 32:327-337
BACKGROUND: Recent studies demonstrated the involvement of mesenchymal stem/stromal cells (MSCs) in carcinogenesis, but the molecular mechanism behind this transformation is still obscured. OBJECTIVE: To screen both the expression levels of polycomb
Publikováno v:
Journal of Alzheimer's Disease. 84:869-881
Background: The most prevalent kind of dementia, Alzheimer’s disease (AD), is a neurodegenerative disease. Previous research has shown that glycogen synthase kinase-3β (GSK-3β) is involved in the etiology and progression of AD, including amyloid-
Autor:
Yanyan Qiu, Fei Liu, Junze Bao, Xiaomin Yin, Zheng Zhou, Chenxu Liu, Chenhao Zhao, Xing Fan, Wei Qian
Publikováno v:
Journal of Alzheimer's Disease. 84:895-904
Background: Amyloid plaques and neurofibrillary tangles are two pathological hallmarks of Alzheimer’s disease (AD). However, synaptic deficits occur much earlier and correlate stronger with cognitive decline than amyloid plaques and neurofibrillary
Publikováno v:
J Alzheimers Dis
Background: Dominant missense mutations in the amyloid-β protein precursor (AβPP) cause early-onset familial Alzheimer’s disease (FAD) and are associated with changes in the production or properties of the amyloid-β peptide (Aβ), particularly o
Publikováno v:
Journal of Alzheimer's Disease. 83:367-377
Background: Imbalance between amyloid-β (Aβ) production and clearance results in Aβ accumulation. Regulating Aβ levels is still a hot point in the research of Alzheimer’s disease (AD). Objective: To identify the differential expression of ATP-b
Publikováno v:
Journal of Alzheimer's Disease
Background: Aberrant cell cycle re-entry is a well-documented process occurring early in Alzheimer’s disease (AD). This is an early feature of the disease and may contribute to disease pathogenesis. Objective: To assess the effect of forced neurona
Publikováno v:
Journal of Alzheimer's Disease. 82:149-157
Silent information-regulated transcription factor 1 (SIRT1) is the most prominent and widely studied member of the sirtuins (a family of mammalian class III histone deacetylases). It is a nuclear protein, and the deacetylation of the peroxisome proli
Autor:
Yi Li, Sidra Tabassum, Cheng Long, Li Yang, Jian Chen, Xingzhi Zheng, Ming Chen, Qingwei Huo, Mengyao Sun, Yueming Deng
Publikováno v:
Journal of Alzheimer's Disease. 81:1469-1482
Background: Neuropathological features of Alzheimer’s disease are characterized by the deposition of amyloid-β (Aβ) plaques and impairments in synaptic activity and memory. However, we know little about the physiological role of amyloid-β protei