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Publikováno v:
Journal of Alzheimer's Disease. 84:869-881
Background: The most prevalent kind of dementia, Alzheimer’s disease (AD), is a neurodegenerative disease. Previous research has shown that glycogen synthase kinase-3β (GSK-3β) is involved in the etiology and progression of AD, including amyloid-
Publikováno v:
Cancer Biomarkers. 21:179-186
PI3K/Akt/mTOR signaling pathway plays an important role in tumor development. mTOR overexpression and PI3K/ Akt/mTOR signaling pathway enhancement were found in endometrial cancer (EC). MiR-101 was found downregulated in EC. Bioinformatics analysis s
Autor:
Chad Slawson, Jeffrey Thompson, Reegan Miller, Heather M. Wilkins, Russell H. Swerdlow, Sarah Griffith, Amy Qiang, Gentry K. Cork, Jarrod Flax
Publikováno v:
J Alzheimers Dis
Background: Alzheimer’s disease (AD) features reductions in key bioenergetic fluxes and perturbed mitochondrial function. Cytoplasmic hybrids (cybrids) generated through the transfer of AD subject mitochondria to mtDNA-depleted SH-SY5Y neuroblastom
Autor:
Jianhui Man, Qihao Zhang, Zhijian Su, Yadong Huang, Dong Peng, Tian Meng, Hongxia Chen, Qi Xiang, Qin Cao
Publikováno v:
Journal of Alzheimer's Disease. 72:97-109
Glycogen synthase kinase 3β (GSK3β) is a key component of pathogenesis in Alzheimer's disease, and its inhibitors can restore cognitive function as therapeutic interventions in neurodegenerative diseases. The previous studies showed that acidic fib
Publikováno v:
J Alzheimers Dis
Mounting evidence has identified that impaired amyloid-β (Aβ) clearance might contribute to Alzheimer's disease (AD) pathology. The lysosome-autophagy network plays an important role in protein homeostasis and cell health by removing abnormal prote
Autor:
Charles R. Vanderburg, David S Cohen, Eric R. Rosin, Xudong Huang, Maximilian Strunz, Juliet T Jarrell
Publikováno v:
Journal of Alzheimer's Disease
Alzheimer's disease (AD) is an age-related progressive form of dementia that features neuronal loss, intracellular tau, and extracellular amyloid-β (Aβ) protein deposition. Neurodegeneration is accompanied by neuroinflammation mainly involving micr
Publikováno v:
Cancer Biomarkers. 22:575-585
Objective To investigate the impact of Bmi-1-mediated NF-κB pathway on the biological characteristics of CD133+ liver cancer stem cells (LCSCs). Methods Flow cytometry was used to isolate CD133+ LCSC cells from Huh7, Hep3B, SK-hep1, and PLC/PRF-5 ce
Autor:
Alejandra del C. Alonso, Leah S. Cohen
Publikováno v:
Journal of Alzheimer's Disease. 64:S507-S516
The microtubule associated protein tau in a hyperphosphorylated form was identified as the building block of the filamentous aggregates found in the neurons of Alzheimer's disease (AD) patients. In the abnormal state, hyperphosphorylated tau from AD
Publikováno v:
Journal of Alzheimer's Disease. 63:1173-1189
Oxidative stress and amyloid-β (Aβ) oligomers have been implicated in Alzheimer's disease (AD). The growth and maintenance of neuronal networks are influenced by brain derived neurotrophic factor (BDNF) expression, which is promoted by protein kina
Publikováno v:
Journal of Alzheimer's Disease. 62:1789-1801
As the primary mediator for synaptic transmission, AMPA receptors (AMPARs) are crucial for synaptic plasticity and higher brain functions. A downregulation of AMPAR expression has been indicated as one of the early pathological molecular alterations