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Publikováno v:
Journal of Alzheimer's Disease. 84:869-881
Background: The most prevalent kind of dementia, Alzheimer’s disease (AD), is a neurodegenerative disease. Previous research has shown that glycogen synthase kinase-3β (GSK-3β) is involved in the etiology and progression of AD, including amyloid-
Publikováno v:
J Alzheimers Dis
Background: Dominant missense mutations in the amyloid-β protein precursor (AβPP) cause early-onset familial Alzheimer’s disease (FAD) and are associated with changes in the production or properties of the amyloid-β peptide (Aβ), particularly o
Publikováno v:
Journal of Alzheimer's Disease. 83:367-377
Background: Imbalance between amyloid-β (Aβ) production and clearance results in Aβ accumulation. Regulating Aβ levels is still a hot point in the research of Alzheimer’s disease (AD). Objective: To identify the differential expression of ATP-b
Publikováno v:
Journal of Alzheimer's Disease
Background: Aberrant cell cycle re-entry is a well-documented process occurring early in Alzheimer’s disease (AD). This is an early feature of the disease and may contribute to disease pathogenesis. Objective: To assess the effect of forced neurona
Autor:
Ottavio Arancio, Rose Pitstick, Michael P. Kavanaugh, Russell E. Nicholls, Agnieszka Staniszewski, Madhumathi Gnanaprakash, Hong Zhang
Publikováno v:
Journal of Alzheimer's Disease
Background: The serine/threonine protein phosphatase, PP2A, is thought to play a central role in the molecular pathogenesis of Alzheimer’s disease (AD), and the activity and substrate specificity of PP2A is regulated, in part, through methylation a
Autor:
Ivone Carvalho, Jéssica Ellen Barbosa de Freitas Lima, Natália Chermont Dos Santos Moreira, Talita Perez Cantuaria Chierrito, Elza Tiemi Sakamoto-Hojo
Publikováno v:
Journal of Alzheimer's Disease. 78:353-370
Background: Alzheimer’s disease (AD) is characterized by a progressive loss of episodic memory associated with amyloid-β peptide aggregation and the abnormal phosphorylation of the tau protein, leading to the loss of cholinergic function. Acetylch
Publikováno v:
Journal of Alzheimer's Disease. 77:85-98
Background: Long noncoding RNAs have been proven to play an important role in the progression of Alzheimer’s disease (AD). However, the function of small nucleolar RNA host gene 1 (SNHG1) in AD progression remains to be studied. Objective: To explo
Autor:
Prashant Bharadwaj, Ralph N. Martins
Publikováno v:
Journal of Alzheimer's Disease
Increased amyloid-β (Aβ) accumulation associated with abnormal autophagy-lysosomal activity and nutrient kinase dysregulation are common features in Alzheimer's disease (AD) brain. Recent studies have identified PRKAG2 and TIPRL genes that control
Publikováno v:
Journal of Alzheimer's Disease. 73:909-917
Exosomes are nano-sized extracellular vesicles that are secreted by cells and usually found in body fluids. Since they freely cross the blood-brain barrier, neuronal exosomes respond directly to changes in the brain's environment. Recent studies have
Autor:
Allan Stensballe, Kenneth Kastaniegaard, Christiane Volbracht, Joakim Bastrup, Ayodeji A. Asuni
Publikováno v:
Bastrup, J, Kastaniegaard, K, Asuni, A A, Volbracht, C & Stensballe, A 2020, ' Proteomic and Unbiased Post-Translational Modification Profiling of Amyloid Plaques and Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 73, no. 1, pp. 393-411 . https://doi.org/10.3233/JAD-190652
Amyloid plaques are one of the hallmarks of Alzheimer's disease (AD). The main constituent of amyloid plaques is amyloid-β peptides, but a complex interplay of other infiltrating proteins also co-localizes. We hypothesized that proteomic analysis co