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Autor:
Anand Kolatkar, Peter Kuhn, Samir Damani, Sarah E. Topol, Eric J. Topol, Kelly Bethel, Mohsen Sabouri-Ghomi, Madelyn Luttgen, Rachelle Lamy
Publikováno v:
Physical Biology. 11:016002
Elevated levels of circulating endothelial cells (CECs) occur in response to various pathological conditions including myocardial infarction (MI). Here, we adapted a fluid phase biopsy technology platform that successfully detects circulating tumor c
Publikováno v:
Physical Biology. 10:056010
Patients with acute myelogenous leukemia (AML) are at risk for thrombotic complications. Risk to develop thrombosis is closely tied to leukemia subtype, and studies have shown an association between leukocytosis and thrombosis in AML M3. We evaluated
Publikováno v:
Physical Biology. 10:036003
Thrombosis significantly contributes to cancer morbidity and mortality. The mechanism behind thrombosis in cancer may be circulating tissue factor (TF), as levels of circulating TF are associated with thrombosis. However, circulating TF antigen level
Publikováno v:
Physical Biology. 9:065002
Cancer may result from localized failure of instructive cues that normally orchestrate cell behaviors toward the patterning needs of the organism. Steady-state gradients of transmembrane voltage (V(mem)) in non-neural cells are instructive, epigeneti
Autor:
Kelly Bethel, Peter Kuhn
Publikováno v:
Physical Biology. 9:010301
Reliable measurement of internal bodily substances and structures is one of the cornerstones of modern medicine. Progress in cancer medicine, like that in many medical fields, must encompass and take advantage of progress in the physical sciences. Hi
Autor:
Alison Morgan, Peter Kuhn, Kelly Bethel, Madelyn Luttgen, Anand Kolatkar, Marco Wendel, Ethan Schram, Daniel C. Lazar, Craig Yoshioka, Edward H. Cho, Jorge Nieva, Dena Marrinucci, W. Michael Korn, Lyudmila Bazhenova, Andrew H. Ko
Publikováno v:
Physical Biology. 9:016001
Circulating tumor cells (CTCs) have been implicated as a population of cells that may seed metastasis and venous thromboembolism (VTE), two major causes of mortality in cancer patients. Thus far, existing CTC detection technologies have been unable t
Autor:
Edward H. Cho, Kelly Bethel, Meghana Honnatti, Michel M. van den Heuvel, Marco Wendel, Anthony Perricone, Peter Kuhn, Rogier C. Boshuizen, Anand Kolatkar, Patricia A. Thistlethwaite, Lyudmila Bazhenova, Jorge Nieva, Dena Marrinucci, Ajay Sandhu
Publikováno v:
Physical Biology. 9:016005
Circulating tumor cell (CTC) counts are an established prognostic marker in metastatic prostate, breast and colorectal cancer, and recent data suggest a similar role in late stage non-small cell lung cancer (NSCLC). However, due to sensitivity constr
Publikováno v:
Physical Biology. 8:066005
Tissue factor (TF) is a transmembrane glycoprotein cofactor of activated blood coagulation factor VII (FVIIa) that is required for hemostatic thrombin generation at sites of blood vessel injury. Membrane-associated TF detected in circulating blood of