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Autor:
Sukki Cho, Min Jung Kim, Jin Eun Choi, Jae Yong Park, Ji Young Park, Seung Soo Yoo, Chang Ho Kim, Eung Bae Lee, Seung Ick Cha, Hyo Sung Jeon, Guang Jin, Tae In Park, Shin Yup Lee, Tae Hoon Jung
Publikováno v:
Journal of Thoracic Oncology. (11):1734-1740
Introduction:Epidermal growth factor receptor (EGFR) signaling pathway plays a crucial role in the development and progression of lung cancer. We searched for mutations of EGFR pathway genes in non-small cell lung cancers (NSCLCs) and analyzed their
Autor:
Tetsuro Baba, Koji Kuroda, Kosei Yasumoto, Yoshiki Shigematsu, Mitsuhiro Takenoyama, Tetsuya So, Tomoko So, Hidetaka Uramoto, Takeshi Hanagiri, Yoshika Nagata
Publikováno v:
Journal of Thoracic Oncology. (8):1136-1142
Introduction The identification of activating mutations in the epidermal growth factor receptor ( EGFR ) gene is one of the most intriguing recent discoveries in the field of lung cancer research, and they are more commonly found in adenocarcinoma oc
Autor:
Kazuhiko Nakagawa, Isamu Okamoto, Takashi Kinoshita, Akihiko Kawahara, Satoshi Hattori, Masayoshi Kage, Shinzo Takamori, Mayumi Ono, Tomoki Taira, Koichi Azuma, Masayuki Takeda, Kazutaka Nakashima, Michihiko Kuwano
Publikováno v:
Journal of Thoracic Oncology. (1):122-127
IntroductionSomatic mutations in the epidermal growth factor receptor (EGFR) gene are associated with an increased response to EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib in patients with non-small cell lung cancer (NSCLC). Although most
Autor:
Godefridus J. Peters, Laura Boldrini, Gabriella Fontanini, Romano Danesi, Enrico Vasile, Carmelo Tibaldi, Roberto Incensati, Elisa Giovannetti, I. Bernardini, Marielle I. Gallegos-Ruiz, Federico Cappuzzo
Publikováno v:
Journal of Thoracic Oncology, 6(2), 395-396. International Association for the Study of Lung Cancer
Tibaldi, C, Giovannetti, E, Vasile, E, Boldrini, L, Gallegos-Ruiz, M I, Bernardini, I, Incensati, R, Danesi, R, Cappuzzo, F, Peters, G J & Fontanini, G 2011, ' Inherited Germline T790M Mutation and Somatic Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer Patients ', Journal of Thoracic Oncology, vol. 6, no. 2, pp. 395-396 . https://doi.org/10.1097/JTO.0b013e3182059a6f
Tibaldi, C, Giovannetti, E, Vasile, E, Boldrini, L, Gallegos-Ruiz, M I, Bernardini, I, Incensati, R, Danesi, R, Cappuzzo, F, Peters, G J & Fontanini, G 2011, ' Inherited Germline T790M Mutation and Somatic Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer Patients ', Journal of Thoracic Oncology, vol. 6, no. 2, pp. 395-396 . https://doi.org/10.1097/JTO.0b013e3182059a6f
Five cases of non-small cell lung cancer, associated with germline transmission of epidermal growth factor receptor (EGFR)-T790M mutation, have been reported1; these patients had family histories of lung cancer. The activity of gefitinib was tested i