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pro vyhledávání: '"Raymond Rothstein"'
Autor:
Qihui Huang, Stacy Fuhrmann, Jonathan Rios-Doria, Kelly McGlinchey, Robert E. Hollingsworth, Carl Hay, Edmund Poon, Nick Holoweckyj, Erin Sult, Ching Ching Leow, Ronald Herbst, Gundo Diedrich, Melissa Damschroder, Kris Sachsenmeier, Nicholas M. Durham, Kathy Mulgrew, Raymond Rothstein, Scott A. Hammond
Publikováno v:
Oncoimmunology
MEDI9447 is a human monoclonal antibody that is specific for the ectoenzyme CD73 and currently undergoing Phase I clinical trials. Here we show that MEDI9447 is a potent inhibitor of CD73 ectonucleotidase activity, with wide ranging immune regulatory