Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Olena Barbash"'
Autor:
J. Nathaniel Diehl, Zhaorui Lian, Kurt D'Andrea, Katherine L. Nathanson, Weiqi Sheng, Eric K. Lee, Ravi Amaravaradi, Shujing Liu, Meenhard Herlyn, Lynn M. Schuchter, Xiaowei Xu, J. Alan Diehl, Dariusz Pytel, Olena Barbash, Richard Letrero
Publikováno v:
Molecular and Cellular Biology. 33:4422-4433
Cyclin D1-cyclin-dependent kinase 4/6 (CDK4/6) dysregulation is a major contributor to melanomagenesis. Clinical evidence has revealed that p16(INK4A), an allosteric inhibitor of CDK4/6, is inactivated in over half of human melanomas, and numerous an
Autor:
Olena Barbash, Anil K. Rustgi, Mariusz A. Wasik, Andres J. Klein-Szanto, Laura Pontano Vaites, Darshan Roy, J A Diehl, Zhaorui Lian, Eric K. Lee
Publikováno v:
Molecular and Cellular Biology. 31:4513-4523
Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complexes modulate the accumulation of key cell cycle regulatory proteins. Following the G(1)/S transition, SCF(Fbx4) targets cyclin D1 for proteasomal degradation, a critical event necessary for DNA replicat
Autor:
Priya Aggarwal, Craig H. Bassing, J. Alan Diehl, Olena Barbash, Laura L. Pontano, Eric J. Brown
Publikováno v:
Molecular and Cellular Biology. 28:7245-7258
While mitogenic induction of cyclin D1 contributes to cell cycle progression, ubiquitin-mediated proteolysis buffers this accumulation and prevents aberrant proliferation. Because the failure to degrade cyclin D1 during S-phase triggers DNA rereplica