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pro vyhledávání: '"Mark A Wainberg"'
Publikováno v:
Expert Opinion on Investigational Drugs. 26:1207-1213
To date, three HIV integrase strand transfer inhibitors (INSTIs), i.e. raltegravir, elvitegravir and dolutegravir, have been approved for clinical use. Recent research has focused on new integrase inhibitors including those targeting non-catalytic si
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:2019-2024
The inhibition of HIV-1 replication in vitro by Immunor 28 (IM28), an analog of dehydroepiandrosterone (DHEA), was monitored using the HIV-1 laboratory wild-type strain IIIB. Evaluation of the 50% inhibitory dose (IC50) revealed a decrease in HIV-1 r
Autor:
Alexander A. Krayevsky, Horacio Salomón, Maureen Oliveira, Mark A. Wainberg, John Machado, Christos Tsoukas
Publikováno v:
Nucleosides and Nucleotides. 18:901-906
Both AZT and its novel 5′-hydrogen phosphonate derivative, Phosphazid, possess similar in vitro activity and resistance profiles. Experiments involving AZT-resistant virus isolates revealed a strong correlation between resistance to AZT and cross-r
Autor:
Antonietta R. Belmonte, Kazushige Nagai, Horacio Salomón, Tarek S. Mansour, Mark A. Wainberg, Nathalie Richard
Publikováno v:
Nucleosides and Nucleotides. 16:1235-1240
We have selected for resistance against a novel compound, (+) dOTFC, using HIV-1 tissue culture replication assays. A novel D67G (asp gly) mutation in HIV-1 reverse transcriptase has been identified that confers about 5-fold resistance to this drug b
Autor:
Albert D. Friesen, Elena Duta, Michael I. Anazodo, Jim A. Wright, Mark A. Wainberg, Horacio Salomon
Publikováno v:
Nucleosides and Nucleotides. 16:1241-1249
Fully thioated antisense molecules are often cytotoxic and non-specitic in action. GPI2A is thioated at 7 base positions. GPI2A posses sequence-specific activity against HIV-1 gene expression and viral replication without sigdcant cytotoxicity. Parti
Autor:
John Gillard, Claire Ashman, Horacio Salomon, Elizabeth Hooker, Haolun Jin, Antonietta R. Belmonte, Nick Cammack, Colleen A. Evans, Wei Wang, Mark A. Wainberg, Bernard Belleau, Dilip M. Dixit, Tarek S. Mansour, H. L. Allan Tse
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 14:627-635
3′-Oxa-4′-thiocytidine nucleoside analogues 14–17 were prepared from oxathiolanes 10 and 11, and evaluated for activity against HIV-1 and HBV in vitro. The nucleoside analogues were found to possess potent activities against HIV-1 in a panel of
Autor:
Mark A. Wainberg
Publikováno v:
HIV/AIDS (Auckland, N.Z.)
HIV/AIDS: Research and Palliative Care, Vol 2013, Iss default, Pp 41-49 (2013)
HIV/AIDS: Research and Palliative Care, Vol 2013, Iss default, Pp 41-49 (2013)
Mark A WainbergMcGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, CanadaAbstract: A recent addition to the anti-human immunodeficiency virus armamentarium of drugs is rilpivirine, which is a potent non-nuc