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pro vyhledávání: '"Jeffrey E. DeClue"'
Autor:
Alex G. Papageorge, Douglas R. Lowy, Jeffrey E. DeClue, Xiaolan Qian, Pieter H. Anborgh, William C. Vass
Publikováno v:
Molecular and Cellular Biology. 19:4611-4622
Ras GTPases, which play a pivotal role as transducers of various mitogenic and differentiation signals, function as molecular switches, cycling between an inactive GDP-bound state and an active GTP-bound state (33). Ras is negatively regulated by GTP
Autor:
S. Felzmann, D R Lowy, Gangfeng Xu, M. R. Johnson, William C. Vass, R. White, Jeffrey E. DeClue
Publikováno v:
Molecular and Cellular Biology. 14:641-645
The NF1 gene, which is altered in patients with type 1 neurofibromatosis, has been postulated to function as a tumor suppressor gene. The NF1 protein product neurofibromin stimulates the intrinsic GTPase activity of active GTP-bound Ras, thereby inac
Autor:
Jeffrey E. DeClue, D R Lowy, Ke Zhang, R. A. Blanchard, P. Martin, Alex G. Papageorge, J. C. Stone
Publikováno v:
Molecular and Cellular Biology. 11:3132-3138
A series of v-rasH effector domain mutants were analyzed for their ability to transform rat 2 cells at either low or high temperatures. Three mutants were found to be significantly temperature sensitive: Ile-36 changed to Leu, Ser-39 changed to Cys (