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Publikováno v:
Immunopharmacology and Immunotoxicology. 43:758-766
Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) exposure might be considerably associated with a decreased risk of Alzheimer's disease (AD). Therefore, we conducted an experiment to investigate the impact of indomethacin (IND) on inflammaso
Publikováno v:
Drug and Chemical Toxicology. 45:2568-2575
Gentamicin (GM) is an antibiotic belonging to an aminoglycoside family that might induce nephrotoxicity in human and animal models via oxidative stress. Toll-like receptors (TLRs) are part of innat...
Publikováno v:
Drug and Chemical Toxicology. 45:1558-1564
The β-adrenoceptor blockers may have anti-oxidant properties or induce β-arrestin recruitment beyond classical desensitization of receptor/G protein coupling, offering potential therapeutic benefits. Here, we investigated the effects of carvedilol,
Autor:
Peiyuan Yu, Gengyang Shen, Jingjing Tang, Hui Ren, De Liang, Wenhua Zhao, Xiang Yu, Yu-zhuo Zhang, Qi Shang, Yongqiang Lu, Xiaobing Jiang, Zhida Zhang
Publikováno v:
Climacteric. 24:179-186
The aim of this study was to investigate the role of the insulin-like growth factor-1 receptor (IGF-1R)Rats were divided into four groups. The sham group received sham operation and a single intraperitoneal administration of vehicle. The ovariectomy
Publikováno v:
Journal of Receptors and Signal Transduction. 40:133-140
Objective: Hyperglycemia-mediated cardiomyocyte damage is associated with inflammation and AMPK inactivation.Aim: The aim of our study is to explore the protective effects exerted by liraglutide on AMPK pathway and glucagon-like peptide 1 receptor in
Publikováno v:
Neurological Research. 42:108-117
Objective: The possible effect of NMDAR (N-methyl-D-aspartate receptor)-NMNAT1/2 (nicotinamide/nicotinic acid mono-nucleotide adenylyltransferase) signaling pathway on the neuronal cell dam...
Publikováno v:
Stress
Evidence implicates the endocannabinoid (eCB) system as a negative modulator of neural and endocrine responses to acute stressors. Recently, eCB signaling was also reported to contribute to habituation of hypothalamo-pituitary-adrenal (HPA) axis resp
Autor:
Hamid Reza Sadeghnia, Farimah Beheshti, Mohammad Soukhtanloo, Yousef Baghcheghi, Mahmoud Hosseini, Mohammad Naser Shafei, Hossein Salmani, Alireza Ebrahimzadeh Bideskan
Publikováno v:
International Journal of Neuroscience. 129:1024-1038
Aim: The effect of peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist pioglitazone on the brain tissues oxidative damage and learning and memory impairment in the juvenile hypoth...
Autor:
Sayo Tomita, Shin-ichiro Miura, Yasunori Suematsu, Yoshino Matsuo, Takashi Kuwano, Kohei Tashiro, Ken Kitajima
Publikováno v:
Clinical and Experimental Hypertension. 41:747-752
BACKGROUND: We hypothesized that the 5-oxo-1,2,4-oxadiazole moiety of azilsartan (AZL), which represents a small difference in the molecular structures of AZL and candesartan (CAN) [angiotensin II type 1 receptor (AT1R) blockers], may be responsible
Autor:
Libin Xiao, Lingjing Jin, Yanwen Zhou, Wuchao Liu, Ying Liu, Yunhua Hao, Bing Li, Ya Feng, Zhiyu Nie, Lizhen Pan
Publikováno v:
Drug Design, Development and Therapy
Yanwen Zhou,* Ying Liu,* Yunhua Hao, Ya Feng, Lizhen Pan, Wuchao Liu, Bing Li, Libin Xiao, Lingjing Jin, Zhiyu Nie Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China *These authors contribu