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Autor:
Maxwell Sehested, Jiri Bartek, Niels E. Skakkebæk, Jiri Lukas, Michael B. Kastan, Christopher J. Bakkenist, Jirina Bartkova, Ewa Rajpert-De Meyts
Publikováno v:
Cell Cycle. 4:838-845
The ATM kinase is a tumor suppressor and key regulator of biological responses to DNA damage. Cultured cells respond to genotoxic insults that induce DNA double-strand breaks by prompt activation of ATM through its autophosphorylation on serine 1981.