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Publikováno v:
Xenobiotica. 22:51-55
1. The effects of hypophysectomy and androgen treatment on the urinary excretion of zenarestat were investigated in Sprague-Dawley rats. 2. Hypophysectomized male rats and normal female rats has similar urinary excretion of zenarestat which was much
Publikováno v:
Xenobiotica. 21:1347-1355
1. The pharmacokinetics of Casodex, a novel, non-steroidal antiandrogen, have been investigated following single oral and i.v. doses and during daily oral dosing to male and female rats and male dogs. 2. The binding of 14C-Casodex to rat, dog and hum
Publikováno v:
Xenobiotica. 21:1003-1011
1. Betamethasone (1 mg/ml) was administered i.v. to adult Wistar rats 3 h before paraquat injection (30 mg/ml) and various parameters of lung function were studied to determine the effect of an anti-inflammatory drug in paraquat lung toxicity. 2. Rat
Publikováno v:
Journal of Receptor Research. 11:743-756
Estradiol (E2) regulation of estrogen receptor (ER) concentrations has been shown to be both time- and dose-dependent. E2 concentrations of 0.5 mg/ml or greater contained in Silastic capsules suppressed uterine ER concentrations after one day's expos
Publikováno v:
Xenobiotica. 20:45-54
1. The metabolism of 2,4-dibromoethynyloestradiol (2,4-DBEE2) in the rat was studied in order to determine the influence of ring-A substituents on the phase I biotransformations of oestrogens. 2. 2,4-Dibromo-17 alpha-ethynyl[6,7-3H]oestradiol was syn
Publikováno v:
Journal of Toxicology and Environmental Health. 8:141-150
Perinatal exposure to polybrominated biphenyls (PBBs) increased the hepatic microsomal metabolism of estradiol, estrone, and ethynylestradiol in vitro. Pretreatment with PBBs decreased the effect of estradiol administered exogenously on uterine estro
Autor:
Catherine L. Marsh, Arthur A. Hancock
Publikováno v:
Journal of Receptor Research. 5:311-334
Desipramine (DMI), decreased the maximum number of beta-adrenergic receptors by approximately 10, 20, 30, and 20% in groups of rats treated i.p. with 5 mg/kg for 14 days or 10 mg/kg for 7, 14, or 21 days, respectively. In studies of agonist competiti
Publikováno v:
Journal of Receptor Research. 3:439-450
Rat testis membranes possess insulin receptor whose autoregulation is different from conventional insulin target organs. In order to verify the importance of the functional activity of the Leydig cells, different approaches were selected to provoke a
Publikováno v:
Journal of Receptor Research. 7:695-712
We have examined the ability of various antiestrogens (AE's) to compete with 3H-spiroperidol for binding to membrane preparations from striatal tissue and anterior pituitary glands of immature female rats in order to determine the affinity of binding
Autor:
C. K. Phares, B. J. M. Booth
Publikováno v:
Journal of Receptor Research. 6:425-446
Somatogenic hormones play an important role in regulation of receptors for prolactin (PRL) and estrogen. Plerocercoids of the tapeworm, S. mansonoides produce a factor which mimics some, but not all of the actions reported for GH. Intact female rats