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pro vyhledávání: '"Maria Gabriella Gabrielli"'
Autor:
G Fasolis, Maria Gabriella Gabrielli, del Vecchio Mt, R Rossie, Luca Puccetti, S.A. Tripodi, Silvia Pastorekova, and Andrea Scozzafava, C.T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 19:287-291
Clear renal cell carcinomas (RCC) frequently express carbonic anydrase IX (CA IX) because of non-functional mutation of von Hippel Lindau (VHL) tumor suppressor gene. CA IX is a tumor-associated transmembrane antigen, which catalyzes the extracellula