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Publikováno v:
Xenobiotica. 26:333-345
1. An hplc method with fluorescence derivatization was developed for the quantification of remikiren in plasma (limit of quantification 2 ng/ml). This was used to determine the pharmacokinetics in various species of primate, in which the compound is
Publikováno v:
Xenobiotica. 23:781-798
1. Casodex, a non-steroidal antiandrogen, was eliminated primarily in faeces by rat, mouse, rabbit and dog. Rat, mouse and rabbit eliminated 20-30% of a single oral dose (8-25 mg/kg) in urine; only 3-4% was excreted in urine by dog (2.5 mg/kg). Oral
Autor:
Keiji Izushi, Mitsunobu Mio, Masaaki Akagi, Kenji Tasaka, Chiaki Kamei, Kazuhiro Kitazumi, Shigehiro Masaki
Publikováno v:
Immunopharmacology and Immunotoxicology. 14:191-205
Epinastine caused an inhibition of histamine release from rat peritoneal mast cells induced by both antigen-antibody reaction and compound 48/80. Epinastine was similarly effective in inhibiting compound 48/80-induced histamine release not only from
Autor:
J. F. Hills, L. A. McKown, J F Pritchard, J A Uetz, K T Ng, Wu-Nan Wu, P J O'Neill, K A Yorgey
Publikováno v:
Xenobiotica. 22:153-169
1. The disposition and pharmacokinetics of bepridil (Bp) were studied in mouse, rat, rabbit, rhesus monkey, and man. Bp was essentially completely absorbed by all species. 2. Maximum plasma Bp concentrations were achieved within 2 h of drug administr
Autor:
Toshinori Kamiyama, Fumiaki Marumo, Happei Miyakawa, T Shigesawa, Jin-Hong Liu, Kazuo Tajiri, Chifumi Sato
Publikováno v:
Xenobiotica. 22:433-437
1. The effects of caffeine on the NADPH-dependent production of paracetamol-glutathione conjugate were studied in rat and mouse liver microsomes. 2. In the presence of caffeine, glutathione conjugate production in rat microsomes was enhanced, whereas
Publikováno v:
Xenobiotica. 22:171-184
1. The disposition of 14C-minaprine was studied after oral administration of 5 and 20 mg/kg to rats, dogs and macaques, and of 200 mg to human volunteers with a genetic status of either limited or extensive hydroxylation of debrisoquine. 2. The drug
Publikováno v:
Xenobiotica. 22:217-226
1. High parenteral doses of a twice-daily schedule of d,l-fenfluramine (d,l-F) may cause long-lasting decrease of functional indices of brain serotoninergic neurones in rats. The single- and multiple-dose (b.i.d. x 4 days) kinetics of low (1.25 mg/kg
Publikováno v:
Xenobiotica. 21:1077-1084
1. Livers from rats treated acutely with ethanol showed increased chemiluminescence, malondialdehyde production, and diene formation. Previous administration of (+)-cyanidanol-3 completely abolished acute ethanol-induced chemiluminescence. 2. Rats fe
Publikováno v:
Xenobiotica. 21:1159-1169
1. To investigate the metabolites and biliary excretion of new camptothecin analogue, irinotecan, the drug was administered i.v. to rats (10 mg/kg) and bile, urine and faeces were collected. 2. In rat bile, unchanged irinotecan, the metabolite 7-ethy
Autor:
K Simizu, Silvia Berlanga de Moraes Barros, Virgínia Berlanga Campos Junqueira, Luis A. Videla
Publikováno v:
Xenobiotica. 21:1023-1032
1. Lindane (25-60 mg/kg) at 24 h after dosage induced a dose-dependent increase in oxygen consumption by perfused rat livers, an effect not observed at early times (2-6 h) after administration. About 60% of the increase in liver oxygen uptake is supp