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Publikováno v:
Xenobiotica. 21:53-63
1. Rats were exposed to m-xylene (300 ppm) and methyl ethyl ketone (MEK, 600 ppm) vapour, separately and in combination. 2. Repeated exposures to m-xylene enhanced liver drug-metabolizing capacity, whereas MEK showed no effects. After mixed exposure
Autor:
Osvaldo R. Koch, Virgínia Berlanga Campos Junqueira, K Simizu, Ligia Ajaime Azzalis, R. Pimentel, Luis A. Videla, Silvia Berlanga de Moraes Barros
Publikováno v:
Xenobiotica. 21:1053-1065
1. Lindane administered to untreated rats or rats pretreated with phenobarbital (PB) or 3-methylcholanthrene (MC) increased liver lipid peroxidation, of the same magnitude in all groups. 2. PB pretreatment produced a 50% increase in lipid peroxidatio
Publikováno v:
Xenobiotica. 21:1003-1011
1. Betamethasone (1 mg/ml) was administered i.v. to adult Wistar rats 3 h before paraquat injection (30 mg/ml) and various parameters of lung function were studied to determine the effect of an anti-inflammatory drug in paraquat lung toxicity. 2. Rat
Publikováno v:
Drug and Chemical Toxicology. 13:209-219
The effect of repeated cephaloridine treatment on renal glutathione and related enzymes has been investigated in young adult male and female Sprague-Dawley rats. Animals were given intraperitoneally daily doses of either 750mg/kg for two weeks or 500
Publikováno v:
Drug and Chemical Toxicology. 12:61-66
Increased vascular permeability, as measured by changes in skin weight and Evans blue dye extravasation, was produced in the skin after immersion of the anesthetized rat's paw in 12 N hydrochloric, 18N sulfuric, or 14N hydrofluoric acids for 2 min. C
Autor:
Christopher P. Chengelis
Publikováno v:
Xenobiotica. 18:1211-1224
1. A study of the sex- and age- (4 to 103 weeks) related changes in liver microsomal mixed-function oxidase components of Sprague-Dawley rats, showed that total cytochrome P-450 ranged from 12.0 to 34.0 nmol/g, peaking between weeks 26 and 39; males
Publikováno v:
Drug and Chemical Toxicology. 6:259-266
The in vivo effects of chlordane on brain Na+-K+, oligomycinsensitive (O.S) and oligomycin-insensitive (O.I) Mg2+ ATPases in rats were investigated. The rats were fed on 0, 25, 50 and 100 ppm chlordane mixed with iron-sufficient (I.S) and deficient (
Publikováno v:
Xenobiotica. 14:885-892
1. The elimination kinetics of disopyramide, [14C]disopyramideand [2H]disopyramide have been studied in the isolated perfused rat liver.2. Disappearance of disopyramide from perfusate was dose- and time-dependent over the dose range 0-3-7-5 mg. Altho
Autor:
Kenneth Ramos, Daniel Acosta
Publikováno v:
Journal of Toxicology and Environmental Health. 14:137-143
Primary cultures of myocardial cells were used to evaluate the cardiotoxic potential of various tricyclic antidepressants (TCAs). Lactate dehydrogenase (LDH) leakage, cellular viability, and beating rates were measured to compare the cardiotoxicity o
Publikováno v:
Drug and Chemical Toxicology. 6:317-328
In adult female Wistar rats, pretreated by gavage with two doses - 16 or 256 mumol/kg - of cyanamide, TMTD (tetramethylthiuram disulfide), TMTM (tetramethylthiuram monosulfide), Ziram or Zineb at 90 min or 18 h before administration of 2 g of ethanol