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Autor:
Margherita Annicchiarico-Petruzzelli, Yufang Shi, Maria Vittoria Cannizzaro, Elena Campione, Marco Galluzzo, Mara Mancini, Ying Wang, Valentina Rovella, Gerry Melino, Roberta Gaziano, Caterina Lanna, Marina Talamonti, Luca Bianchi
Publikováno v:
Cell Cycle
The skin is a peripheral lymphoid organ, being the first immunological defense against infections as the initial interface between the organism and the external background. The maintenance of the skin immune homeostasis depends on a finely equilibriu
Autor:
Joanne A. Hammill, Bojana Bojovic, Craig Aarts, Jonathan L. Bramson, Anna Dvorkin-Gheva, Vivan W.C. Lau, Raja Ghosh, Seung Mi Yoo, Gregory R. Steinberg
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Oncoimmunology
article-version (VoR) Version of Record
Oncoimmunology
article-version (VoR) Version of Record
Engineered T cell therapies have revolutionized modern oncology, however processes for manufacturing T cell therapies vary and the impact of manufacturing processes On the cell product is poorly understood. Herein, we have used a commercially availab
Autor:
Mie Linder Hübbe, Evelina Martinenaite, Morten Orebo Holmström, Inge Marie Svane, Marco Carretta, Stine Emilie Weis-Banke, Simone Kloch Bendtsen, Ayako Wakatsuki Pedersen, Daniel H. Madsen, Mia Aaboe Jørgensen, Mads Hald Andersen, Özcan Met, Niels Ødum
Publikováno v:
Oncoimmunology
article-version (VoR) Version of Record
OncoImmunology, Vol 9, Iss 1 (2020)
Weis-Banke, S E, Hübbe, M L, Holmström, M O, Jørgensen, M A, Bendtsen, S K, Martinenaite, E, Carretta, M, Svane, I M, Ødum, N, Pedersen, A W, Met, Ö, Madsen, D H & Andersen, M H 2020, ' The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines ', OncoImmunology, vol. 9, no. 1, 1771142 . https://doi.org/10.1080/2162402X.2020.1771142
article-version (VoR) Version of Record
OncoImmunology, Vol 9, Iss 1 (2020)
Weis-Banke, S E, Hübbe, M L, Holmström, M O, Jørgensen, M A, Bendtsen, S K, Martinenaite, E, Carretta, M, Svane, I M, Ødum, N, Pedersen, A W, Met, Ö, Madsen, D H & Andersen, M H 2020, ' The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines ', OncoImmunology, vol. 9, no. 1, 1771142 . https://doi.org/10.1080/2162402X.2020.1771142
One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2). Here we describe the existence of pro-inflammatory effector T-cells that recognize ARG2 and can directly target
Autor:
Thomas J. Carpenter, Xiefan Lin-Schmidt, Wenbo Chen, Donald Heald, Weirong Wang, Xirong Zheng, Alice Zong, Aman P. Singh
Publikováno v:
mAbs
The development of mechanism-based, multiscale pharmacokinetic–pharmacodynamic (PK-PD) models for chimeric antigen receptor (CAR)-T cells is needed to enable investigation of in vitro and in vivo correlation of CAR-T cell responses and to facilitat
Autor:
Xi Chen, Hugh M. Davis, Rebecca Zhou, Jun Wang, Donald Heald, Weirong Wang, Xiling Jiang, Thomas J. Carpenter
Publikováno v:
mAbs. 10:876-889
T-cell redirecting bispecific antibodies (bsAbs) or antibody-derived agents that combine tumor antigen recognition with CD3-mediated T cell recruitment are highly potent tumor-killing molecules. Despite the tremendous progress achieved in the last de
Autor:
Dashan Wang
Publikováno v:
Immunopharmacology and Immunotoxicology. 40:187-192
AIM The aim of this paper is to clarify the critical role of GPCR signaling in T cell immunity. METHODS The G protein-coupled receptors (GPCRs) are the most common targets in current pharmaceutical industry, and represent the largest and most versati
Publikováno v:
Journal of Immunotoxicology, Vol 14, Iss 1, Pp 1-8 (2017)
Exposure to arsenic (As) is an ongoing, and in some places increasing, health problem. Still, however, the effects of As exposure on the immune system are not well understood. Dendritic cells (DC) are a critical immune cell that bridges the innate an
Autor:
Helga Schmetzer, Marion Merle, Markus Freudenreich, Dorothea Fischbacher, Claus-Henning Koehne, Julia Dreyßig, Tanja Kroell, Andreas Kremser, Hans-Jochem Kolb, Christine Grabrucker, Arndt Borkhardt, Christoph Schmid, Anja Liepert, Doris Kraemer, Friedhelm R. Schuster
Publikováno v:
Cell Commun. Adhes. 22, 49-65 (2016)
To enlighten interactions between autologous, allogeneic or T-cells from patients after stem cell transplantation with leukaemia-derived-dendritic-cells containing dendritic cells or blast containing mononuclear cells (n = 21, respectively), we d
Autor:
Jeak Ling Ding, P. Panneerselvam
Publikováno v:
International Reviews of Immunology. 34:432-444
SARM (Sterile alpha and armadillo motif-containing protein) is the recently identified TIR domain-containing cytosolic protein. Classified as a member of the TLR adaptor family, the multiple locations and functions of SARM (sometimes playing opposing
Autor:
Dalia Abd Elaziz, Safa Meshaal, Nermeen Galal, Jeannette Boutros, Rabab El Hawary, Diana Nagy, Reem Jan Farid, Ingy Fikry, Radwa Alkady, Aisha Elmarsafy
Publikováno v:
Journal of Receptors and Signal Transduction. 35:423-428
Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder caused by inherited defects in the NADPH oxidase complex which may be involved in important pathways that connect innate and adaptive immunity.Characterize the naive and memor