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Autor:
Acong Yang, Shuo Gu, Bao Tran, Xavier Bofill-De Ros, Lisheng Dai, Sean Chen, Chuanjiang Lian, Tony Shi, Lillian Hallmark, Yongmei Zhao, Howard Crouch
Publikováno v:
RNA Biol
MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22-nucleotide (nt) in length that collectively regulate more than 60% of coding genes. Aberrant miRNA expression is associated with numerous diseases, including cancer. miRNA biogenesis is
Publikováno v:
RNA Biol
The X-linked CDKL5 gene codes for a kinase whose mutations have been associated with a suite of neurodevelopmental disorders generally characterized by early-onset epileptic encephalopathy and severe intellectual disability. The impact of these mutat
Autor:
Charly R. Good, Morgan A. Sammons, Allison N. Catizone, Katherine A. Alexander, Shelley L. Berger
Publikováno v:
Cell Cycle
The tumor suppressor protein p53 is activated in response to diverse intrinsic and extrinsic cellular stresses and controls a broad cell-protective gene network. Whether p53:DNA binding and subsequent transcriptional activation differs downstream of
Autor:
Samuel Pushparaj, Yurong Liang, Xiaoyun Yang, Roshini Sathiaseelan, Zhengyu Zhu, Kong Lin, Sunil More, Chaoqun Huang, Lin Liu
Publikováno v:
RNA Biology. 16:340-353
Long non-coding RNAs (lncRNAs) are a new arm of gene regulatory mechanism as discovered by sequencing techniques and follow-up functional studies. There are only few studies on lncRNAs as related to gene expression regulation and anti-viral activity
Publikováno v:
Emerging Microbes & Infections
Viruses regulate cellular signalling pathways to ensure optimal viral replication. During Marburg virus (MARV) infection, large quantities of the viral glycoprotein GP are produced in the ER; this may result in the activation of the unfolded protein
Autor:
Caitlin E. Purman, Eugene M. Oltz, Patrick L. Collins, Harshath Gupta, Barry P. Sleckman, Sofia I. Porter, Ankita Saini
Publikováno v:
Mol Cell Biol
DNA damage responses (DDR) to double-strand breaks (DSBs) alter cellular transcription programs at the genome-wide level. Through processes that are less well understood, DSBs also alter transcriptional responses locally, which may be important for e
Publikováno v:
Cell Cycle. 17:1931-1945
Tuberculosis (TB), caused by Mycobacterium tuberculosis, could lead to kinds of clinical disorders and remains a leading global health problem, resulting in great morbidity and mortality worldwide. Previous studies have firmly demonstrated that M. tu
Autor:
Guodong Xiao, Ning Du, Yuan Li, Dapeng Liu, Xin Sun, Hong Ren, Shou Ching Tang, Meng Wang, Rui Liang, Gang Li
Publikováno v:
Cell Cycle. 17:1445-1456
MiR-146a could stimulate tumor growth or block tumor proliferation in systemic malignancies, referring to the specific downstream targeted gene. However, its roles in breast cancer stem-like cells (BrCSCs) are barely known. To dig out its mechanistic
Publikováno v:
Prion. 11:388-397
The normal function of PrPC, the cellular prion protein, has remained mysterious since its first description over 30 years ago. Amazingly, although complete deletion of the gene encoding PrPC has little phenotypic consequence, expression in transgeni
Publikováno v:
Journal of Asthma. 55:15-25
To investigate the effects of interferon-γ (IFN-γ) on the proliferation and viability of human embryonic lung Mrc-5 fibroblasts in vitro and the expression of the A Disintegrin and Metalloprotease 33 (ADAM33) gene and to explore the mechanism of ai