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Autor:
Sumanprava Giri, Susan Wopat, Supriya G. Prasanth, Dazhen Liu, Arindam Chakraborty, Yating Wang, Yo-Chuen Lin, Rosaline Y.C. Hsu, Kannanganattu V. Prasanth
Publikováno v:
Cell Cycle
RFWD3 is an E3 ubiquitin ligase that plays important roles in DNA damage response and DNA replication. We have previously demonstrated that the stabilization of RFWD3 by PCNA at the replication fork enables ubiquitination of the single-stranded bindi
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 39:1320-1334
CAD, the multienzymatic protein that initiates and controls the de novo biosynthesis of pyrimidines, plays a major role in nucleotide homeostasis, cell growth and proliferation. Despite its interest as a potential antitumoral target, there is a lack
Publikováno v:
Cutaneous and Ocular Toxicology. 37:267-274
To investigate the protective effect of beta-casomorphin-7 (β-CM-7) in oxidative stressed human lens epithelial cells (HLECs) and to explore the possible mechanism for oxidative stress in HLECs induced by high glucose.We used HLECs to determine the
Autor:
Soojin Yoon, Daehan Lim, Hanna Park, Ahruem Baek, Dong-Eun Kim, Hye Won Chung, Yu Mi Baek, Jean Kim
Publikováno v:
Autophagy. 13:248-263
Contribution of autophagy and regulation of related proteins to the degeneration of retinal pigment epithelium (RPE) in age-related macular degeneration (AMD) remain unknown. We report that upregulation of KRT8 (keratin 8) as well as its phosphorylat
Autor:
Aruni S. Arachchige-Don, Mary C. Horne, Tommaso Patriarchi, Michaela S. Donaldson, Maike Zimmermann
Publikováno v:
Cell cycle (Georgetown, Tex.), vol 15, iss 23
Definition of cell cycle control proteins that modify tumor cell resistance to estrogen (E2) signaling antagonists could inform clinical choice for estrogen receptor positive (ER+) breast cancer (BC) therapy. Cyclin G2 (CycG2) is upregulated during c
Autor:
Rommie E. Amaro, Daniel J. Salamango, Adam Z. Cheng, Jennifer L. McCann, Reuben S. Harris, William L. Brown, Özlem Demir, Jordan T. Becker, Nadine M. Shaban
Publikováno v:
Molecular and Cellular Biology
APOBEC enzymes are DNA cytosine deaminases that normally serve as virus restriction factors, but several members, including APOBEC3H, also contribute to cancer mutagenesis. Despite their importance in multiple fields, little is known about cellular p
Autor:
Caroline C. Philpott, James A. Wohlschlegel, Ajay A. Vashisht, Kimberly Z. Bullough, Fengmin Li
Publikováno v:
Molecular and Cellular Biology. 36:2121-2131
Poly(rC)-binding proteins (PCBPs) are multifunctional adapters that mediate interactions between nucleic acids, iron cofactors, and other proteins, affecting the fates and activities of the components of these interactions. Here, we show that PCBP2 f
Autor:
Xia Lin, Jiahuai Han, Yanzhen Chen, Pinglong Xu, Xin-Hua Feng, Zhengmao Zhang, Chao Wang, Mu Xiao, Fenfang Chen, Bin Zhao
Publikováno v:
Molecular and Cellular Biology. 35:1700-1711
Bone morphogenetic proteins (BMPs) play vital roles in regulating stem cell maintenance and differentiation. BMPs can induce osteogenesis and inhibit myogenesis of mesenchymal stem cells. Canonical BMP signaling is stringently controlled through reve
Publikováno v:
Nucleus
The eukaryotic nucleus is structurally and functionally organized, as reflected in the distribution of its protein and DNA components. The genome itself is segregated into euchromatin and heterochromatin that replicate in a distinct spatio-temporal m
Publikováno v:
Molecular and Cellular Biology. 34:2464-2478
A cancer is a robustly evolving cell population originating from a normal diploid cell. Improper chromosome segregation causes aneuploidy, a driving force of cancer development and malignant progression. Telomeric repeat binding factor 1 (TRF1) has b