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Autor:
Mikio Hayashi, Ivana Novak
Publikováno v:
Hayashi, M & Novak, I 2013, ' Molecular basis of potassium channels in pancreatic duct epithelial cells ', Channels (Austin), vol. 7, no. 6, pp. 432-441 . https://doi.org/10.4161/chan.26100
Channels
Channels
Potassium channels regulate excitability, epithelial ion transport, proliferation, and apoptosis. In pancreatic ducts, K(+) channels hyperpolarize the membrane potential and provide the driving force for anion secretion. This review focuses on the mo
Publikováno v:
Channels. 6:290-307
The acquisition of cell motility plays a critical role in the spread of prostate cancer (PC), therefore, identifying a sensitive step that regulates PC cell migration should provide a promising target to block PC metastasis. Here, we report that a me
Autor:
Yu-Wen Lin, Diva D. De León, Nkecha Hughes, Alejandro Akrouh, YeouChing Hsu, Colin G. Nichols
Publikováno v:
Channels. 6:133-138
KATP channels regulate insulin secretion by coupling β-cell metabolism to membrane excitability. These channels are comprised of a pore-forming Kir6.2 tetramer which is enveloped by four regulatory SUR1 subunits. ATP acts on Kir6.2 to stabilize the
Autor:
Petronel Tuluc, Bernhard E. Flucher
Publikováno v:
Channels. 5:518-524
One of the earliest steps in the development of the neuromuscular junction (NMJ) is the pre-patterning of acetylcholine receptors (AChR) in the center of muscle fibers. This process has recently been proposed to depend on L-type calcium currents. But
Publikováno v:
Channels. 1:353-365
Nitrogen oxides exert significant but diverse regulatory effects on cardiac myocytes. Many of these effects are due to modulation of voltage-sensitive ion channel function. The redox-status of NO-related compounds is a critical factor in determining
Publikováno v:
Connective Tissue Research. 28:49-70
Effects of applied hydrostatic pressure on transmembrane potentials were investigated in sheep articular chondrocytes and human skin fibroblasts in non-confluent monolayer cultures. Resting potentials in chondrocytes (about -12 mv) and in fibroblasts
Publikováno v:
Channels
Klotho is a transmembrane protein expressed primarily in kidney, parathyroid gland, and choroid plexus. The extracellular domain could be cleaved off and released into the systemic circulation. Klotho is in part effective as β-glucuronidase regulati