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Autor:
Colin G. Nichols, Robert C. Tryon, Maria S. Remedi, Nathaniel W. York, Jennifer Ikle, Soma S. Singareddy
Publikováno v:
Islets. 14:200-209
KATP channel gain- (GOF) and loss-of-function (LOF) mutations in SUR1 or Kir6.2 underlie human neonatal diabetes mellitus (NDM) and congenital hyperinsulinism (CHI), respectively. Genetically modified mice with transgenic overexpression of GOF mutati
Publikováno v:
Scandinavian Journal of Clinical and Laboratory Investigation. :1-6
This study aimed to establish age- and sex-specific reference intervals for serum amylase and lipase in children by prospective investigation. A total of 6466 healthy Han children of 1 month ∼18 years were recruited in communities and schools in fi
Publikováno v:
International Journal of Neuroscience. :1-21
Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder with complex etiology that eventually leads to dementia. The main culprit of AD is the extracellular deposition of β-amyloid (Aβ) and intracellular neurofibrillary tangles. The
Autor:
Markus H. Kuehn, Abhigna Akurathi, Erin A. Boese, Matthew M. Harper, Johannes Ledolter, Randy H. Kardon
Publikováno v:
Current Eye Research. 47:597-605
Purpose The purpose of this study was to examine the expression of glial derived neurotrophic factor (GDNF), the GDNF receptors GFRα1 and GFRα2, ciliary neurotrophic factor (CNTF), and the CNTF receptor CNTFRα in normal and glaucomatous human tiss
Publikováno v:
International Journal of Neuroscience. 133:123-132
Purpose: Chronic renal failure (CRF) is associated with impairment of hippocampal neurons. This study investigated the effect of PERK-eIF2α-ATF4 pathway in CRF.Methods: Rat CRF model was established and rat hippocampal neurons were separated. Xanthi
Publikováno v:
Journal of Drug Targeting
The recent outbreak of SARS CoV-2 has changed the global scenario of human lives/economy. A significant number of the non-survivors showed cardiac-renal-vasculature dysfunction. A 'cytokine storm' namely, interleukin IL6-IL1 receptors i.e. IL6R-IL1R
Publikováno v:
Biomarkers. 27:222-229
Cystatin C has been identified as an independent predictor of all-cause and cardiovascular mortality in the general population. This meta-analysis to evaluate the association between serum cystatin C level and all-cause and cardiovascular mortality.
Publikováno v:
Bioengineered, Vol 13, Iss 2, Pp 2720-2731 (2022)
Sirtuin-3 (SIRT3) has been described as a colorectal cancer oncogene and to be regulated by glycyrrhizic acid (GA). However, few studies have explored the interaction between GA and SIRT3. Therefore, in the present study, we showed that GA could sign
Publikováno v:
Bioengineered, Vol 13, Iss 2, Pp 2017-2027 (2022)
Osteoarthritis (OA) affects approximately 12% of the aging Western population. The sirtuin/forkhead box O (SIRT/FOXO) signaling pathway plays essential roles in various biological processes. Despite it has been demonstrated that ubiquitin-specific pr
Autor:
Gemma Safont, L Marín, P. Sierra, Ana Garcia-Blanco, L. de la Fuente, M.P. García-Portilla, Belén Arranz, Marina Garriga, Mónica Sanchez-Autet
Publikováno v:
The World Journal of Biological Psychiatry. 23:464-474
OBJECTIVES Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-Reactive Protein (CRP) are markers of inflammation that are elevated in bipolar disorder (BD) and are also related to a higher risk of metabolic syndrome (MetS). Thi