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Publikováno v:
Cell Cycle
This study examined the potential roles of CC10 (Clara cell 10-kD protein) and ILC2s (type 2 innate lymphoid cells) in allergic rhinitis (AR). After ovalbumin was used to construct the AR model, microarray analysis was performed to reveal the key dif
Autor:
Lihua Fang, Chengqiang Zhang, Rui Li, Gailian Zhang, Tingting Nie, Luping Cui, Jie Wang, Xiaoping Liu
Publikováno v:
Autoimmunity. 54:336-342
Chondrocyte apoptosis contributes to osteoarthritis, while miR-146a is a critical player in chondrocyte apoptosis. Our bioinformatics analysis showed that miR-146a may bind with long non-coding RNA (lncRNA) CALML3 antisense RNA 1 (CALML3-AS1). Our st
Publikováno v:
Autoimmunity. 54:313-325
Although long non-coding RNA LINC00963 has been reported to play a crucial regulatory role in osteoporosis (OP), its specific mechanism has not been well studied. Cell viability of human bone marrow mesenchymal stem cells (hBMSCs) transfected with sh
Autor:
Li Hualan, liu wenzhong
Publikováno v:
Autoimmunity
article-version (VoR) Version of Record
article-version (VoR) Version of Record
At present, the novel coronavirus pneumonia has been widespread worldwide, and there is no specific medicine. In response to the emergency, we adopted bioinformatics methods to study the virus's pathogenic mechanism and found possible control methods
Autor:
Lori G Morton, Adelekan Oyejide, Qian Zhang, Li Pan, David J. Glass, Sara Hamon, Jianing Xu, Anita Boyapati, Dharani Ajithdoss, Tea Shavlakadze, Christos A. Kyratsous, Matthew F. Wipperman, Matthew Wakai, Raphael Simonson, Megan McAleavy, Abhilash Gadi, Peter J. Ehmann
Publikováno v:
Molecular and Cellular Biology
A subset of hospitalized COVID-19 patients, particularly the aged and those with comorbidities, develop the most severe form of the disease, characterized by acute respiratory disease syndrome (ARDS), coincident with experiencing a “cytokine storm.
Autor:
Lei You, Zhen Luo, Junbo Chen, Weiyong Liu, Yingle Liu, Kailang Wu, Qi Zhang, Wenbiao Wang, Wei Xu, Qi Xiang, Jianguo Wu
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 537-553 (2020)
Virulence
Virulence
Enterovirus 71 (EV71) infection causes hand, foot, and mouth disease (HFMD), and even fatal neurological complications. However, the mechanisms underlying EV71 neurological pathogeneses are largely unknown. This study reveals a distinct mechanism by
Autor:
Mohammad Ramezani, Maryam Sadat Nabavinia, Seyed Mohammad Taghdisi, Houshang Rafatpanah, Mostafa Khedri, Khalil Abnous
Publikováno v:
Immunological Investigations. 49:535-554
Programmed cell death protein 1 (PD1; also known as CD279) is an inhibitory receptor on T lymphocytes interacting with PD1-ligand 1 and PD1-ligand 2 in the synapse of T cells and antigen presenting cells (APC) resulting in the suppression of T cell a
Publikováno v:
Journal of Immunotoxicology
Journal of Immunotoxicology, Vol 17, Iss 1, Pp 86-93 (2020)
Journal of Immunotoxicology, Vol 17, Iss 1, Pp 86-93 (2020)
Many persistent organic pollutants, such as polychlorinated biphenyls (PCBs), have high immunomodulating potentials. Exposure to them, in combination with virus infections, has been shown to aggravate outcomes of the infection, leading to increased v
Autor:
Jonathan Werner, Edward K. Lobenhofer, Mercedesz Balazs, Madeline M. Fort, Ana Goyos, Marc A. Lafleur
Publikováno v:
Journal of Immunotoxicology, Vol 17, Iss 1, Pp 110-121 (2020)
Mast cells play key roles in allergy, anaphylaxis/anaphylactoid reactions, and defense against pathogens/toxins. These cells contain cytoplasmic granules with a wide spectrum of pleotropic mediators that are released upon activation. While mast cell
Autor:
Margherita Annicchiarico-Petruzzelli, Yufang Shi, Maria Vittoria Cannizzaro, Elena Campione, Marco Galluzzo, Mara Mancini, Ying Wang, Valentina Rovella, Gerry Melino, Roberta Gaziano, Caterina Lanna, Marina Talamonti, Luca Bianchi
Publikováno v:
Cell Cycle
The skin is a peripheral lymphoid organ, being the first immunological defense against infections as the initial interface between the organism and the external background. The maintenance of the skin immune homeostasis depends on a finely equilibriu