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pro vyhledávání: '"Maria Sasvari-Szekely"'
Autor:
Tatjana Spasokoukotskaja, Maria Staub, Staffan Eriksson, Gergely Keszler, Maria Sasvari-Szekely
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 25:1147-1151
The activity of deoxycytidine kinase (dCK) has been shown to be enhanced upon genotoxic stress in human lymphocytes, and reversible phosphorylation of the enzyme has been implicated in the activation process. Here, we provide compelling evidence that
Publikováno v:
Nucleosides and Nucleotides. 15:1657-1668
Thymidine (Thd) was phosphorylated to dTTP also at 0°C, both in Ehrlich ascites tumor cells and human tonsillar lymphocytes, but was not incorporated into DNA. The uptake and phosphorylation of 14C-Thd into the pool showed regular kinetics (Km 6, 6