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Autor:
Darshini Desai, Manoj Govindarajulu, Timothy Moore, Edwin McElroy, Satyanarayana R. Pondugula, Eddie Fahoury, Mohammed Almaghrabi, Rishi Nadar, Kristina Gill, Kodye L. Abbott, Muralikrishnan Dhanasekaran, Sindhu Ramesh, Mohammed Majrashi, Natasha Narayanan
Publikováno v:
Toxicology Mechanisms and Methods. 30:454-461
Endogenous (hyperglycemia) and exogenous (therapeutic, prophylactic, street drugs) factors can considerably contribute to cognitive impairment (CI). Currently, there are few invasive and/or noninvasive markers that correlate with CI and those that do
Autor:
Vaibhav Gaur, Anil Kumar
Publikováno v:
Drug and Chemical Toxicology. 35:218-224
Involvement of the glutathione system is well established in stroke-induced memory dysfunction. The aim of the present study was to investigate the effects of celecoxib (a selective cyclooxygenase-2 [COX-2] inhibitor), nimesulide (a preferential COX-
Autor:
Helena Maria Tannhauser Barros, Paulo Hilário Nascimento Saldiva, Ana Claudia Zanchi, Claudia Ramos Rhoden, Mitiko Saiki, Carina Duarte Venturini
Publikováno v:
Inhalation Toxicology. 20:795-800
Several epidemiological studies have linked particulate matter exposure to numerous adverse health effects on the respiratory, cardiovascular, and reproductive systems (Braga et al., 1999; Zanobetti et al., 2000; Anderson et al., 2001; Farhat et al.,
Autor:
Sara H Bullman, Eman M. EL-Masry, Larry B. Goldstein, Mohamed B. Abou-Donia, Anjelika Dechkovskaia, Ali Abdel-Rahman, Wasiuddin A. Khan
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 67:331-356
Malathion (O,O-dimethyl-S-[1,2-carbethoxyethyl]phosphorodithionate), DEET (N,N-diethyl-m-toluamide), and permethrin [(+/-)-cis/trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylic acid (3-phenoxyphenyl) methyl ester] are commonly used pe
Autor:
Herink J, Gabriela Krejčová, F. Skopec, Jiří Kassa, Jiří Bajgar, Miloš Tichý, Miroslav Pecka, Lucie Ševelová
Publikováno v:
Inhalation Toxicology. 16:517-530
Long-term effects of low doses of highly toxic organophosphorus agent sarin on various hematological and biochemical markers and physiological functions were studied in rats exposed to sarin by inhalation. The results indicate that low-level sarin-ex
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 63:253-271
Excessive dietary intake of sugars could alter various biotransformation processes and the pharmacological and toxicological properties of numerous xenobiotics. In the present study, the effects of glucose supplementation were examined on the neuroto
Autor:
João Palermo-Neto, F R Silva
Publikováno v:
Immunopharmacology and Immunotoxicology. 21:247-265
In utero exposure of rats to low dosages of diazepam (1.0-2.0 mg/kg) has been found to result in depression of the cellular and humoral immune responses during adulthood. Behavioral dysfunctions were also reported in infants from mothers with high be
Publikováno v:
Drug and Chemical Toxicology. 15:217-232
Male and female Sprague-Dawley rats were administered drinking water containing 300, 600, 1200, or 2400 mg/L chloral hydrate for 90 days. A control group received distilled water only. No animals died during the study and no differences were observed
Publikováno v:
Drug and Chemical Toxicology. 15:177-201
The accelerating rotarod was used to assess motor performance decrement in rats after administration of candidate anticonvulsant compounds (acetazolamide, amitriptyline, chlordiazepoxide, diazepam, diazepam-lysine, lorazepam, loprazolam, midazolam, p
Autor:
Casey P. Robinson, Paul W. Smith
Publikováno v:
Journal of Toxicology and Environmental Health. 3:565-568
Depletion of serotonin or norepinephrine in male rats by pretreatment with p-chlorophenylalanine or DL-alpha-methyl-p-tyrosine, respectively, failed to reduce the lethality of the monoamine oxidase-inhibiting acaricide, chlordimeform. Administration