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Autor:
L. Pivackova, Jan Klimas, Zuzana Kmecova, Eva Velasova, Peter Krenek, E. Malikova, Simona Trubacova, Peter Balis, Gabriel Doka
Publikováno v:
Clinical and Experimental Hypertension. 44:101-112
Background Caveolin-1 (cav-1) plays a role in pulmonary arterial hypertension (PAH). Monocrotaline (MCT)-induced PAH is characterized by a loss of cav-1 in pulmonary arteries; however, less is known regarding its role in the hypertrophied right ventr
Publikováno v:
Adipocyte, Vol 10, Iss 1, Pp 532-545 (2021)
Adipocyte
article-version (VoR) Version of Record
Adipocyte
article-version (VoR) Version of Record
Verapamil can restore intracellular calcium homeostasis, increase the fusion of autophagosomes and lysosomes, reduce lipid droplet accumulation and inhibit inflammation and insulin resistance in high-fat-fed mice. The present study aimed to investiga
Publikováno v:
Gynecological Endocrinology. 37:624-628
The aim of this study is to investigate the effects of metformin treatment at different dosage levels on the ovaries and uteruses of rat offspring in the course of the intrauterine period. Saline, metformin (100 mg/kg/day), and metformin (200 mg/kg/d
Autor:
Nivin Sharawy, Amal Abo El-Maaty, Mona Mohamed Ahmed, Omnia Mohamed Abdel Maksoud, Amr Maher Galal, Laila A. Rashed, Mary Attia Morcos, Maha M Sabry
Publikováno v:
Archives of Physiology and Biochemistry. 128:1391-1400
Mitochondrial impairment is recognised as a prominent feature in kidney diseases. Therefore, we investigated whether the effects of resveratrol, L-carnitine, and apelin in the acute kidney injury model were associated with modulation of mitochondrial
Publikováno v:
Archives of Physiology and Biochemistry. 128:1401-1412
Hyperglycaemic condition induced oxidative stress in diabetic individuals caused oxidative damages of internal organs, including immune organ spleen. We studied the effects of low doses of melatonin (25, 50, and 100 µg/100g. B.wt./day) on histoarchi
Autor:
Heba Morsi, Hanan Abdallah, Ghada Farouk Soliman, Nermeen Bastawy, Walaa Ibrahim, Omnia Mohamed Abdel-Maksoud, Mohamed Mansour Khalifa, Laila A. Rashed
Publikováno v:
Archives of Physiology and Biochemistry. 128:463-473
Aim: High cholesterol diet is greatly linked to deleterious health consequences. In this work we tried to explore direct effects of high cholesterol diet on striated (skeletal and cardiac) muscle tissues and the mechanisms by which nebivolol could im
Publikováno v:
Stress
Evidence implicates the endocannabinoid (eCB) system as a negative modulator of neural and endocrine responses to acute stressors. Recently, eCB signaling was also reported to contribute to habituation of hypothalamo-pituitary-adrenal (HPA) axis resp
Autor:
David J. Kennaway
Publikováno v:
Chronobiology International. 36:1167-1183
There continues to be considerable interest in the physiological role(s) of the hormone melatonin and its potential as a drug more than 60 years after its discovery. While there is an emphasis on human studies, there is still a need for animal models
Publikováno v:
Clinical and Experimental Hypertension. 42:118-125
Background and Objective: Evaluate the activity of dopamine-β-hydroxylase (DβH) as well as the effect of the DβH inhibitor nepicastat upon enzyme activity and levels of dopamine (DA) and norepinephrine (NE) in the rat left ventricle, kidney, and a
Publikováno v:
Stress. 22:256-264
It was hypothesized that there is cross-talk between the classical constituents of the hypothalamo-pituitary-adrenocortical axis (HPA) and Met-enkephalin in the HPA axis. The study examined effects of isolation stress, sex, and age on concentrations