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Autor:
Ting Shen, Zijian Yang
Publikováno v:
Drug Design, Development and Therapy
Ting Shen, Zijian Yang Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai, People’s Republic of ChinaCorrespondence: Zijian YangDepartment of Ophthalmology, Ruijin Hospital Affiliated Medi
Autor:
Hulya Kasıkara, Levent Ozturk, Mustafa Kavutcu, Mustafa Arslan, Nigar Afandiyeva, Ayşegül Küçük, Nuran Sungu
Publikováno v:
Drug Design, Development and Therapy
Hulya Kasıkara,1 Nuran Sungu,2 Mustafa Arslan,3 Aysegul Kucuk,4 Levent Ozturk,5 Nigar Afandiyeva,6 Mustafa Kavutcu6 1Department of Anaesthesiology and Reanimation, Ankara City Hospital, Ankara, Turkey; 2Medical Faculty, Department of Pathology, Y
Publikováno v:
Drug Design, Development and Therapy. 14:5087-5096
Background and purpose Endothelium exerts an important role in releasing vasoactive substances, maintaining the blood flow, regulating the growth of vessels, moderating the process of coagulation, and the balance of fibrinolytic system, the dysfuncti
Autor:
Jicheng TanTai, Yuzhou Shen
Publikováno v:
Drug Design, Development and Therapy. 14:4503-4510
Introduction This study aims to develop a novel co-delivery gefitinib and quercetin system loaded with PLGA-PEG nanoparticles and evaluate their antitumor activity in vitro and in vivo. Methods Gef/Qur NPs were prepared and characterized. The release
Publikováno v:
Drug Design, Development and Therapy. 14:3853-3864
Purpose This research intended to study the mechanism of pravastatin in myocardial ischemia reperfusion (I/R) injury. Patients and methods Altogether 70 male rats were selected and grouped into Sham operation group (Sham group), ischemia reperfusion
Efficacy of Sub-Tenon Micro-Perfusion of Cyclophosphamide in Rabbits with Severe Ocular Inflammation
Publikováno v:
Drug Design, Development and Therapy. 14:3407-3416
Purpose To explore the feasibility of cyclophosphamide (CP) via a sub-Tenon micro-perfusion system (SMS) in rabbits, and assess its therapeutic efficacy in severe ocular inflammation. Materials and methods Distribution and pharmacokinetics of CP were
Autor:
Nur-Vaizura Mohamad, Azlan Mohd Arlamsyah, Sok Kuan Wong, Kok-Yong Chin, Rahma Triliana, Ima Nirwana Soelaiman, Rhivaldy Faahim Kamalulloh, Benjamin Ka Seng Thong
Publikováno v:
Drug Design, Development and Therapy. 14:2561-2572
Purpose Prolonged use of proton pump inhibitors may cause bone loss, and limited therapeutic agents are available to prevent this skeletal side effect. The combination of annatto tocotrienol, a bone anabolic agent, with calcium presents a novel strat
Autor:
Feng Gao, Shanyong Zhang
Publikováno v:
Drug Design, Development and Therapy. 14:2899-2908
Background Chondrocytes in joint tissue are responsible for the synthesis and degradation of the cartilage matrix. Chondrocytes have been closely linked to the pathogenesis of osteoarthritis and cartilage damage. Targeted drug intervention directed a
Autor:
Lingfei Wang, Hongzhang Wu, Xi Wang, Gang Shao, Yueming Meng, Xiaoyuan Jia, Tao Wang, Caiyun Fu, Xurui Cheng, Feiyan Huang, Tianxin Yang
Publikováno v:
Drug Design, Development and Therapy. 14:2413-2422
Purpose Acute myeloid leukemia (AML) is a complex malignancy characterized by the clonal expansion of immature myeloid precursors. The standard treatment for newly diagnosed AML is chemotherapy consisting of cytosine arabinoside (Ara-C) and anthracyc
Publikováno v:
Drug Design, Development and Therapy. 14:2295-2306
Background Subarachnoid hemorrhage (SAH) is a cerebral hemorrhage disease that severely damages the brain and causes cognitive impairment (CI). Therefore, accurate and appropriate treatment strategies are urgently needed. The application of nimodipin