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Autor:
David A. Isenberg, Ana Lorenzo-Vizcaya
Publikováno v:
Expert Opinion on Biological Therapy. 21:639-647
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease characterized by multiple pathologies in which sustained inflammatory activity leads to progressive tissue destruction and organ damage. One of the main proinflammatory cytokines p
Autor:
Ruowen He, Kang Liao, Lan Lan Zhong, Adam P. Roberts, Minmin Lin, Wenbin Deng, Liyan Zhang, Ding Qiang Chen, Klibs N. Galvão, Yong Xia, Hongyu Li, Guo-Bao Tian, Min Dai, Xin Ding, Guanping Chen, Yanxian Yang, Mingyang Qin, Xiaoxue Liang, Yiping Wu, Mohamed Abd El-Gawad El-Sayed Ahmed, Yongqiang Yang, Songyin Huang, Yuan Chen
Publikováno v:
Emerging Microbes & Infections. 10:700-709
Bloodstream infections (BSIs) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) are potentially life-threatening and an urgent threat to public health. The present study aims to clarify the characteristics of carbapenemase-encoding and viru
Autor:
Keren Shi, Xiaoting Hua, Yunsong Yu, Xiaoting Fu, Yue Shi, Qingye Xu, Pengfei Zhu, Sebastian Leptihn, Linyue Zhang, Jingfen Wang, Jintao He, Linghong Zhang, Paul G. Higgins
Publikováno v:
Emerging Microbes & Infections. 10:1404-1417
Acinetobacter baumannii is an important pathogen in hospital acquired infections. Although tigecycline currently remains a potent antibiotic for treating infections caused by multidrug resistant A. baumannii (MDRAB) strains, reports of tigecycline re
Publikováno v:
Emerging Microbes & Infections. 10:1309-1319
The epidemic Streptococcus suis (S. suis) strain [Sequence type (ST) 7] was gradually evolving from the non-epidemic ST1 strain and got the ability for high expressing of suilysin (SLY). And the hi...
Publikováno v:
Expert Opinion on Biological Therapy. 21:303-309
Introduction: One of the latest breakthroughs in the treatment of advanced Non Small Cell Lung Cancer (NSCLC) is represented by PD-1/PD-L1-targeting Immune Checkpoint Inhibitors (ICIs). However, on...
Autor:
Louisa K. James, Harsha H Kariyawasam
Publikováno v:
Drug Design, Development and Therapy. 14:5483-5494
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex, clinically heterogeneous and persistent inflammatory disorder of the upper airway. Detailed mechanistic insights into disease pathogenesis are lacking, but it is now accepted that local
Autor:
Yun Fa Lai, Cheng Hung Lee, Ching Hsiung Lin, Jeng Yuan Hsu, Liang Wen Hang, Jia Horng Wang, Shih Feng Liu, Yu Chih Liu, Shih Lung Cheng, Hao-Chien Wang, Ming Shyang Huang, Ming Lin Ho, Kuang Yao Yang
Publikováno v:
Drug Design, Development and Therapy. 14:5441-5450
Introduction In the prospective, observational, 16-week REACT study conducted between October 21, 2008 and May 12, 2011, we compared the real-world effectiveness of anti-inflammatory reliever and maintenance therapy with budesonide/formoterol (Symbic
Publikováno v:
Drug Design, Development and Therapy. 14:5393-5403
Introduction Carbamoylated erythropoietin (CEPO) is a chemically engineered, nonhematopoietic derivative of erythropoietin (EPO) that retains its antidepressant and pro-cognitive effects, which are attributed to the increased expression of neurotroph
Mini-Tablets versus Nanoparticles for Controlling the Release of Amoxicillin: In vitro/In vivo Study
Autor:
Hessah S Alhawas, Siham Abdoun, Dalia A Gaber, Amal Al-Subaiyel, Fatimah A Alfadhel, Rehab M Alsawi
Publikováno v:
Drug Design, Development and Therapy. 14:5405-5418
Introduction Controlling the drug release from the dosage form at a definite rate is the main challenge for a successful oral controlled-release drug delivery system. In this study, mini-tablets (MTs) and lipid/polymer nanoparticles (LPNs) of lipid p
Publikováno v:
Drug Design, Development and Therapy. 14:5451-5458
Purpose Oxytocin is the first-line agent to prevent and treat uterine atony during cesarean delivery (CD). We compared the effective dose in 50% of the parturients (ED50) of a prophylactic oxytocin bolus during CD in young (