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Publikováno v:
Expert Opinion on Pharmacotherapy
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Introduction: The 4-aminoquinolines, chloroquine, and hydroxychloroquine have been used for over 70 years for malaria and rheumatological conditions, respectively. Their broad-spectrum antiviral activity, excellent safety profile, tolerability, low c
Autor:
James W. Wheless
Publikováno v:
Expert Review of Neurotherapeutics. 21:1195-1205
Introduction: Patients with epilepsy may experience seizure clusters (SCs), which are considered a medical emergency requiring immediate treatment. Besides seizures and seizure-related injuries, pa...
Autor:
Michael D. Staudt, Alan Chalil, Charles Argoff, Elizabeth M Leimer, Ravneet Bhullar, Tessa A. Harland
Publikováno v:
Expert Opinion on Drug Safety. 20:439-451
Introduction: Intrathecal (IT) drug therapy is an effective treatment option for patients with chronic pain of malignant or nonmalignant origin, with an established safety profile and fewer adverse effects compared to oral or parenteral pain medicati
Publikováno v:
Expert Opinion on Orphan Drugs. 9:67-76
Treatment of pediatric adrenal insufficiency (AI) has been challenging due to a lack of dose and age appropriate hydrocortisone preparations for children. Hydrocortisone granules in capsules for op...
Autor:
Giulio Cavalli, Lorenzo Dagna, Nicola Farina, Alessandro Tomelleri, Corrado Campochiaro, Giacomo De Luca
Publikováno v:
Expert Opinion on Orphan Drugs. 9:77-86
Introduction: Still’s disease is a systemic, non-monogenic autoinflammatory condition affecting both children and adolescents (systemic juvenile idiopathic arthritis, sJIA) and adults (adult-onset Still’s disease, AOSD). Its clinical spectrum ran
Publikováno v:
Expert Opinion on Orphan Drugs. 9:95-103
Disseminated fusariosis is a serious fungal infection with a high mortality rate among immunocompromised hosts. Management of fusariosis is challenging due to intrinsic resistance to most available...
Autor:
Dorota Danielak
Publikováno v:
Expert Opinion on Pharmacotherapy. 22:1167-1177
Introduction: Depressive disorders are common in older patients, and their prevalence may reach up to 17.1%. Though for older adults, the initial recommended treatment is either life-review treatment or group cognitive-behavioral therapy, a combinati
Autor:
Hua Bao, Yuefei Cai, Ran Cao, Xue Shen Wu, Lu Zhang, Ping Yang, Liming Peng, Lingling Yang, Yang Shao, Weijun Zhang, Dongqin Zhu
Publikováno v:
OncoTargets and therapy
Background Drug resistance caused by G1202R/G1202del mutation in anaplastic lymphoma kinase (ALK) represents a great challenge in the clinic. The effect of other mutation(s) at G1202 on the available tyrosine kinase inhibitors (TKIs) in the clinic re
Publikováno v:
Journal of Chemotherapy. 33:431-434
Empyema is typically treated using pleural space drainage and systemic treatment with antimicrobials, and specific antimicrobial agents in the case of methicillin-resistant Staphylococcus aureus (M...
Autor:
Wondiwossen Abebe, Surafal Fentaw, Bekele Sharew, Feleke Moges, Gizachew Yismaw, Belay Tessema, Adane Mihret
Publikováno v:
Infection and Drug Resistance
Bekele Sharew,1,2 Feleke Moges,1 Gizachew Yismaw,1 Adane Mihret,3 Wondiwossen Abebe,1 Surafal Fentaw,4 Belay Tessema1 1Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, Universi