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Publikováno v:
International Journal of Neuroscience. 133:123-132
Purpose: Chronic renal failure (CRF) is associated with impairment of hippocampal neurons. This study investigated the effect of PERK-eIF2α-ATF4 pathway in CRF.Methods: Rat CRF model was established and rat hippocampal neurons were separated. Xanthi
Publikováno v:
Journal of Drug Targeting
The recent outbreak of SARS CoV-2 has changed the global scenario of human lives/economy. A significant number of the non-survivors showed cardiac-renal-vasculature dysfunction. A 'cytokine storm' namely, interleukin IL6-IL1 receptors i.e. IL6R-IL1R
Publikováno v:
Canadian Journal of Plant Pathology. 44:1-20
Plants, unlike animals, lack specialized mobile immune cells, so they do not have an adaptive immune system. Instead, plants can launch specific, self-tolerant immune responses and establish immune...
Publikováno v:
Archives of Physiology and Biochemistry. :1-14
Hydrogen sulphide (H2S), a newly identified gasotransmitter, can be endogenously produced by cystathionine gamma-lyase (CSE) in the cardiovascular system. This study investigated the role of the CSE/H2S system on lipid overload-induced lipotoxicity a
Autor:
Gail V.W. Johnson, Jeffrey W. Keillor
Publikováno v:
Expert Opinion on Therapeutic Targets. 25:721-731
Introduction : Transglutaminase 2 (TG2) has been implicated in numerous neurological conditions, including neurodegenerative diseases, multiple sclerosis, and CNS injury. Early studies on the role of TG2 in neurodegenerative conditions focused on its
Publikováno v:
Xenobiotica. 51:977-982
1. Leonurine hydrochloride (LH) is derived from an ingredient of Leonurus japonicus Houtt which is widely used for diseases in women. 2. The influence of LH on the activity of cytochrome P450 (CYPs) enzymes was investigated in this study. 3. The effe
Autor:
Kouichi Yoshinari, Atsushi Suda, Ohminato Noriaki, Kazuhisa Ozeki, Naomi Ono, Norihito Shibahara, Miho Nagayasu, Ryoichi Saitoh
Publikováno v:
Xenobiotica. 51:968-976
The in vitro antitumor activity (e.g., IC50) of anticancer drugs is important for selecting candidate compounds for in vivo drug efficacy study in the early stage of drug discovery. In this study, ...
Mesothelin is Commonly Expressed in Pancreatic Adenocarcinoma but Unrelated to Cancer Aggressiveness
Autor:
Frank Jacobsen, Sören Weidemann, Michael Neipp, Ulf Nahrstedt, Jakob R. Izbicki, Till S. Clauditz, Eike Burandt, Christian Bernreuther, Ronald Simon, Daniel Perez, Till Krech, Hamid Mofid, Stefan Steurer, Thies Daniels, Andreas H. Marx, Kristina Jansen
Publikováno v:
Cancer Investigation. 39:711-720
Data on Mesothelin expression in human normal and cancerous tissues is controversial. We employed immunohistochemistry on a tissue microarray from 599 pancreatic cancers and 12 large tissue sections of pancreatitis. Mesothelin expression was highest
Autor:
Lisa R. Decotret, Carlos Villamil, Donald T. T. Yapp, Kevin L. Bennewith, Brennan J. Wadsworth, Francois Benard, Donald A. Wilson, Michael McKenzie
Publikováno v:
Acta Oncologica. 60:1489-1498
A common feature of solid tumours that are resistant to therapy is the presence of regions with low oxygen content (i.e., hypoxia). Oxygen electrode studies suggest that localized prostate adenocar...
Autor:
Minna Honkanen-Scott, Kirsty S. Cullen, James Shaw, Merilin Georgiou, Penny E. Lovat, Catherine Arden, Vadivel Parthsarathy, Finbarr O'Harte, Stanislaus I Krishnanda, Francesco P Zummo
Publikováno v:
Autophagy. 18:799-815
Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2 diabetes (T2D). We have previously shown that treatment of pancreatic β-cells with the GLP1R (g