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Autor:
Bruno Fattizzo, Mariarita Sciumè, Ramona Cassin, Agostino Cortelezzi, Nicola Orofino, Gianluigi Reda
Publikováno v:
Expert Opinion on Drug Safety. 15:865-873
Obinutuzumab is a novel glycoengineered type II anti-CD20 monoclonal antibody (MoAb) with a higher affinity for CD20 epitope. It was approved by the United States Food and Drug Administration (FDA) in November 2013 for use in combination with chloram
Publikováno v:
Current Medical Research and Opinion. 32:1131-1136
Objective The present study aimed to compare the effects of the dipeptidyl peptidase-4 (DPP-4) inhibitors vildagliptin and saxagliptin on 24 hour acute glucose fluctuations in Chinese patients with type 2 diabetes mellitus (T2DM) inadequately control
Publikováno v:
Expert Opinion on Investigational Drugs. 25:521-529
Bladder pain syndrome (BPS)/interstitial cystitis (IC) is associated with sensory lower urinary tract symptoms. Unfortunately, many of the existing oral treatments are ineffective in most patients of BPS/IC, which is the motivation for developing new
Publikováno v:
Current Medical Research and Opinion. 32:1087-1096
Objective To evaluate glycemic control among patients with type 2 diabetes mellitus (T2DM) treated with canagliflozin (CANA) vs. dipeptidyl peptidase-4 (DPP-4) inhibitors. Methods Using integrated claims and lab data from a US health plan of commerci
Autor:
Matthias Eikermann, Friederike Haerter
Publikováno v:
Expert Opinion on Pharmacotherapy. 17:819-833
Introduction Acetylcholinesterase inhibitors (neostigmine, edrophonium) and encapsulating agents (sugammadex and calabadion) can be used to reverse residual neuromuscular blockade (NMB). Areas covered This review provides information about efficacy,
Autor:
Valentina Gambardella, Susana Roselló, Andrés Cervantes, Juan Miguel Cejalvo, Noelia Tarazona
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 12:449-456
Colorectal cancer is the third most common cancer worldwide. The prognosis of colorectal cancer patients still remains dismal and half of them will develop metastatic disease. Angiogenesis plays an essential role in colorectal tumorigenesis, and the
Publikováno v:
Expert Opinion on Investigational Drugs. 25:423-436
Twenty-six years after the identification of the gene responsible for cystic fibrosis (CF), controversies still surround the pathogenesis of the disease that continues to burden and shorten lives. Therefore, finding effective therapeutic strategies t
Autor:
Guadalupe Garcia-Tsao, Kathleen Yan
Publikováno v:
Expert Opinion on Pharmacotherapy. 17:689-701
Bacterial infections are a serious complication of cirrhosis, as they can lead to decompensation, multiple organ failure, and/or death. Preventing infections is therefore very relevant. Because gut bacterial translocation is their main pathogenic mec
Autor:
Michael Soyka
Publikováno v:
Expert Opinion on Pharmacotherapy. 17:619-626
Few pharmacotherapies are available for alcoholism. Numerous studies indicate the involvement of the opioid-endorphin system in mediating the reinforcing effects of alcohol via dopaminergic neurons. The opioid antagonist naltrexone was found to be ef
Autor:
Matteo Bassetti, Elda Righi
Publikováno v:
Expert Opinion on Drug Safety. 15:467-481
Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent cause of severe nosocomial and community-acquired infections. Various adverse effects have been associated with compounds that are commonly used in the treatment of MRSA.Prolonged use o