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Autor:
Nikhil C. Munshi, Rao Prabhala, Mehmet Kemal Samur, Allison J. Gibbons, Bisweswar Nandi, Jonathan Pastrana Del Valle, Jason S. Gold
Publikováno v:
Oncotarget
CCL20-CCR6 interactions promote colorectal cancer through direct effects on neoplastic epithelial cells and through modulating the tumor microenvironment. The mechanism of these effects on neoplastic epithelial cells is poorly understood. This study
Autor:
Michael E. Mullendore, Deborah Wilsker, Anne Monks, Melinda G. Hollingshead, Lara H. El Touny, Sergio Y. Alcoser, Angie B. Dull, Curtis Hose, Erik Harris, Michelle M. Gottholm-Ahalt, Annamaria Rapisarda, Beverly A. Teicher, Ralph E. Parchment, James H. Doroshow, John Connelly
Publikováno v:
Oncotarget
The therapeutic efficacy of temozolomide (TMZ) is hindered by inherent and acquired resistance. Biomarkers such as MGMT expression and MMR proficiency are used as predictors of response. However, not all MGMTlow/−ve/MMRproficient patients benefit f
Publikováno v:
Oncotarget
Although basal cell carcinoma (BCC) is often managed successfully with surgery, patients with locally advanced BCC (laBCC) or metastatic BCC (mBCC) who are not candidates for surgery or radiotherapy have limited treatment options. Most BCCs result fr
Autor:
Mikhail V. Blagosklonny
Publikováno v:
Oncotarget
Senolytics are basically anti-cancer drugs, repurposed to kill senescent cells selectively. It is even more difficult to selectively kill senescent cells than to kill cancer cells. Based on lessons of cancer therapy, here I suggest how to exploit onc
Publikováno v:
Aging (Albany NY)
Purpose Apatinib resistance is the main obstacle to the effective treatment of advanced head and neck squamous cell carcinoma (HNSCC). This study aimed to evaluate the function of Erb-B2 receptor tyrosine kinase 2 (ERBB2) and stimulator of interferon
Publikováno v:
Aging (Albany NY)
MicroRNAs (miRNAs) contribute to osteoarthritis (OA) development. Nevertheless, the function and mechanism of miR-30b-5p in OA are unclear. In the present article, we gauged the miR-30b-5p level in OA patients and analyzed its correlation with OA sta
Autor:
Guijun Qin, Jingwen Hou, Wang Wang, Gaofei Ren, Yu-Shan Yan, Xiaojun Ma, Zhizhen Li, Min Song
Publikováno v:
Aging (Albany NY)
Background To explore the effect of albiflorin (AL) on streptozotocin (STZ)-induced Alzheimer's disease (AD) in rats. Methods A mouse model of diabetic encephalopathy was established by intraperitoneal injection of 1%STZ. Step down test and water maz
Autor:
Hui-Qing Zeng, Yan Chen, Xiao-Bin Zhang, Kam Yu Chiu, Hui-Juan Cheng, Ya-Ting Yuan, Yi-Yuan Chen
Publikováno v:
Aging (Albany NY)
Chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnea (OSA), is associated with various cardiovascular diseases. In the present study, we assessed the effect of the lipid reducing agent atorvastatin on CIH-induced myocardial oxida
Publikováno v:
Aging (Albany NY)
Background and purpose Obesity is becoming a major global health issue and is mainly induced by the accumulation of adipose tissues mediated by adipogenesis, which is reported to be regulated by peroxisome proliferator-activated receptor γ (PPARγ)
Autor:
Hazel J. Hunt, Andrew E. Greenstein
Publikováno v:
Oncotarget
Background: Resistance to antiproliferative chemotherapies remains a significant challenge in the care of patients with solid tumors. Glucocorticoids, including endogenous cortisol, have been shown to induce pro-survival pathways in epithelial tumor