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Autor:
Nikhil C. Munshi, Rao Prabhala, Mehmet Kemal Samur, Allison J. Gibbons, Bisweswar Nandi, Jonathan Pastrana Del Valle, Jason S. Gold
Publikováno v:
Oncotarget
CCL20-CCR6 interactions promote colorectal cancer through direct effects on neoplastic epithelial cells and through modulating the tumor microenvironment. The mechanism of these effects on neoplastic epithelial cells is poorly understood. This study
Autor:
Michael E. Mullendore, Deborah Wilsker, Anne Monks, Melinda G. Hollingshead, Lara H. El Touny, Sergio Y. Alcoser, Angie B. Dull, Curtis Hose, Erik Harris, Michelle M. Gottholm-Ahalt, Annamaria Rapisarda, Beverly A. Teicher, Ralph E. Parchment, James H. Doroshow, John Connelly
Publikováno v:
Oncotarget
The therapeutic efficacy of temozolomide (TMZ) is hindered by inherent and acquired resistance. Biomarkers such as MGMT expression and MMR proficiency are used as predictors of response. However, not all MGMTlow/−ve/MMRproficient patients benefit f
Publikováno v:
Oncotarget
Although basal cell carcinoma (BCC) is often managed successfully with surgery, patients with locally advanced BCC (laBCC) or metastatic BCC (mBCC) who are not candidates for surgery or radiotherapy have limited treatment options. Most BCCs result fr
Autor:
Mikhail V. Blagosklonny
Publikováno v:
Oncotarget
Senolytics are basically anti-cancer drugs, repurposed to kill senescent cells selectively. It is even more difficult to selectively kill senescent cells than to kill cancer cells. Based on lessons of cancer therapy, here I suggest how to exploit onc
Autor:
Hazel J. Hunt, Andrew E. Greenstein
Publikováno v:
Oncotarget
Background: Resistance to antiproliferative chemotherapies remains a significant challenge in the care of patients with solid tumors. Glucocorticoids, including endogenous cortisol, have been shown to induce pro-survival pathways in epithelial tumor
Autor:
Leila Zemoura, Damien Treguer, Nicolas Girard, Marie Brevet, A. Chapelier, Didier Decaudin, Olivier Deas, Sophie Chateau-Joubert, Stefano Cairo, Rania El Botty, Sergio Roman-Roman, André Nicolas, Didier Meseure, Ivan Bièche, Sophie Vacher, Ludmilla de Plater, Elodie Montaudon, Elisabetta Marangoni, Catherine Daniel, Fariba Nemati, Adnan Naguez, Alain Livartowski
Publikováno v:
Oncotarget. 12:859-872
Significant rational is available for specific targeting of PI3K/AKT/mTOR pathway in the treatment of non-small cell lung cancer (NSCLC). However, almost all clinical trials that have evaluated Pi3K pathway-based monotherapies/combinations did not ob
miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells
Autor:
Carol S. Lutz, Nicholas J. Monteleone
Publikováno v:
Oncotarget
Lung cancer is a collection of aggressive tumors generally not diagnosed until late-stage, resulting in high mortality rates. The vast majority of non-small cell lung cancer (NSCLC) patients undergo combinatory chemotherapeutic treatment, which initi
Publikováno v:
Oncotarget. 11:4104-4114
Objective Women with inherited mutations in BRCA1 gene have a high (40-70%) genetic risk of developing ovarian cancer. Epidemiological studies suggest an inverse correlation between serum vitamin D (VD) levels and the risk of ovarian cancer, but ther
Autor:
Nicholas J. Monteleone, Carol S. Lutz
Publikováno v:
Oncotarget
Many cancers maintain an inflammatory microenvironment to promote their growth. Lung cancer is of particular importance, as it is the deadliest cancer worldwide. One inflammatory pathway commonly dysregulated in cancer is the metabolism of arachidoni
Autor:
Clementina Savastano, Maria Aliberti, G. Colantuoni, Liliana Montella, Olga Fiorentino, Sabino De Placido, Grazia Arpino, Salvatore Del Prete, Ferdinando Riccardi, Carlo Buonerba, Michele Orditura, A. Ruggiero, Giuseppe Buono, Antonio Febbraro, Pasquale Dolce
Publikováno v:
Oncotarget
Despite relevant medical advancements, metastatic breast cancer remains an uncurable disease. HER2 signaling conditions tumor behavior and treatment strategies of HER2 expressing breast cancer. Cancer treatment guidelines uniformly identify dual bloc