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Autor:
Nikhil C. Munshi, Rao Prabhala, Mehmet Kemal Samur, Allison J. Gibbons, Bisweswar Nandi, Jonathan Pastrana Del Valle, Jason S. Gold
Publikováno v:
Oncotarget
CCL20-CCR6 interactions promote colorectal cancer through direct effects on neoplastic epithelial cells and through modulating the tumor microenvironment. The mechanism of these effects on neoplastic epithelial cells is poorly understood. This study
Autor:
Hazel J. Hunt, Andrew E. Greenstein
Publikováno v:
Oncotarget
Background: Resistance to antiproliferative chemotherapies remains a significant challenge in the care of patients with solid tumors. Glucocorticoids, including endogenous cortisol, have been shown to induce pro-survival pathways in epithelial tumor
miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells
Autor:
Carol S. Lutz, Nicholas J. Monteleone
Publikováno v:
Oncotarget
Lung cancer is a collection of aggressive tumors generally not diagnosed until late-stage, resulting in high mortality rates. The vast majority of non-small cell lung cancer (NSCLC) patients undergo combinatory chemotherapeutic treatment, which initi
Autor:
Nicholas J. Monteleone, Carol S. Lutz
Publikováno v:
Oncotarget
Many cancers maintain an inflammatory microenvironment to promote their growth. Lung cancer is of particular importance, as it is the deadliest cancer worldwide. One inflammatory pathway commonly dysregulated in cancer is the metabolism of arachidoni
Autor:
Clementina Savastano, Maria Aliberti, G. Colantuoni, Liliana Montella, Olga Fiorentino, Sabino De Placido, Grazia Arpino, Salvatore Del Prete, Ferdinando Riccardi, Carlo Buonerba, Michele Orditura, A. Ruggiero, Giuseppe Buono, Antonio Febbraro, Pasquale Dolce
Publikováno v:
Oncotarget
Despite relevant medical advancements, metastatic breast cancer remains an uncurable disease. HER2 signaling conditions tumor behavior and treatment strategies of HER2 expressing breast cancer. Cancer treatment guidelines uniformly identify dual bloc
Autor:
Ai Yamaguchi, Michiko Imamura, Yuki Okada, Tomoe Taji, Arisa Nishimukai, Tomoko Higuchi, Ayako Yanai, Takashi Morimoto, Takehiro Yanagawa, Ayako Bun, Hirofumi Suwa, Yuichiro Kikawa, Yasuo Miyoshi, Yoshimasa Miyagawa, Atsushi Sata, Hiromi Ozawa, Chiyomi Egawa, Kaori Takamoto, Yukie Fujimoto, Reiko Fukui, Junichi Inatome
Publikováno v:
Oncotarget
The effect of bevacizumab plus paclitaxel therapy on progression-free survival (PFS) is prominent; however, no overall survival (OS) benefit has been demonstrated. Our aim was to study the predictive efficacy of peripheral immune-related parameters,
Autor:
Gerasimos P. Sykiotis, Nadja Chevalier, Margot Calderoni, Adi Zheng, Gilles Dubuis, Panos G. Ziros, Christian Widmann, Olivier Dormond
Publikováno v:
Oncotarget
Oncotarget, vol. 10, no. 66, pp. 7058-7070
Oncotarget, vol. 10, no. 66, pp. 7058-7070
Sorafenib is the first-line drug used for patients with advanced hepatocellular carcinoma (HCC). However, acquired sorafenib resistance in cancer patients limits its efficacy. Here, we performed the first genome-wide CRISPR/Cas9-based screening on so
Autor:
Larissa S. Meier, Sandra N. Freiberger, Ken Kudura, Olivia Messerli-Odermatt, Jivko Kamarachev, Tamara Rordorf, Reinhard Dummer, Thomas Coppetti, Joanna Mangana, Thierry M Nordmann, Sara Micaletto, Ralph P. Braun, Mirjam Nägeli
Publikováno v:
Oncotarget
Metastatic extramammary Paget’s disease is a rare adenocarcinoma with poor prognosis. Several reports of human epidermal growth factor receptor 2 alterations point to its pathogenic role in the disease. However, the occurrence of treatment resistan
Autor:
Cory D. Fulcher, Carlos Thomas, Nicolas F. Schlecht, Michael B. Prystowsky, Bradley A. Schiff, Richard V. Smith, Andrea Lopez, Nicole Kawachi, Thomas J. Belbin, Gregory Rosenblatt, Evripidis Gavathiotis, Catherine Sarta, Geoffrey Childs, Chandan Guha, Thomas M. Harris, Denis E. Reyna, Thomas J. Ow, Pilib Ó Broin
Publikováno v:
Oncotarget
Mechanisms of treatment resistance in head and neck squamous cell carcinoma (HNSCC) are not well characterized. In this study, HNSCC tumors from a cohort of prospectively enrolled subjects on an ongoing tissue banking study were divided into those th
Autor:
Veronica S. Hughes, Dietmar W. Siemann
Publikováno v:
Oncotarget
C-Met is a frequently overexpressed or amplified receptor tyrosine kinase involved in metastatic-related functions, including migration, invasion, cell survival, and angiogenesis. Because of its role in cancer progression and metastasis, many inhibit